Source:http://linkedlifedata.com/resource/pubmed/id/10534355
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
1999-11-24
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| pubmed:abstractText |
Approximately one third of patients with chronic hepatitis C virus (HCV) infection have normal alanine transaminase (ALT) levels. We studied the clinical, biochemical, virological, and histological features in patients with persistently normal ALT. A case-control study was conducted on 275 patients with chronic HCV infection, including 75 patients with persistently normal ALT and 200 patients with abnormal ALT. Persistently normal ALT was defined as 4 consecutive ALT values in each patient within a period of 12 months. The average age of the patients was 44 years (range 18 to 69 years). More non-Hispanic whites had persistently normal ALT. The mean serum ferritin level was significantly lower in patients with persistently normal ALT as compared with abnormal ALT (128 +/- 92 ng/mL and 224 +/- 128 ng/mL), respectively (P =.017). The mean HCV-RNA level was significantly lower in patients with persistently normal ALT as compared with abnormal ALT (12 x 10(5) +/- 2.8 x 10(6) copies/mL and 33 x 10(5) +/- 8.0 x 10(6)), respectively (P =.02). Histologically, patients with persistently normal ALT had less severe portal inflammation (P <.05), lobular inflammation (P =.003), piecemeal necrosis (P =.002), fibrosis (P <.05), lower prevalence of cirrhosis (P =.007), as well as a slower fibrosis progression rate (P <.001). Chronic hepatitis C patients with persistently normal ALT have low-activity grade and stage on liver biopsy. In these patients the hepatitis C RNA level was lower compared with abnormal ALT patients, which may explain the slower fibrosis progression rate.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Bilirubin,
http://linkedlifedata.com/resource/pubmed/chemical/Ferritins,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0270-9139
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
30
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1307-11
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10534355-Adult,
pubmed-meshheading:10534355-Alanine Transaminase,
pubmed-meshheading:10534355-Bilirubin,
pubmed-meshheading:10534355-Case-Control Studies,
pubmed-meshheading:10534355-Continental Population Groups,
pubmed-meshheading:10534355-Female,
pubmed-meshheading:10534355-Ferritins,
pubmed-meshheading:10534355-Hepatitis C, Chronic,
pubmed-meshheading:10534355-Humans,
pubmed-meshheading:10534355-Inflammation,
pubmed-meshheading:10534355-Iron,
pubmed-meshheading:10534355-Liver,
pubmed-meshheading:10534355-Male,
pubmed-meshheading:10534355-RNA, Viral,
pubmed-meshheading:10534355-Reference Values,
pubmed-meshheading:10534355-Serum Albumin,
pubmed-meshheading:10534355-Sex Characteristics,
pubmed-meshheading:10534355-Southwestern United States
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| pubmed:year |
1999
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| pubmed:articleTitle |
Clinical features of hepatitis C-infected patients with persistently normal alanine transaminase levels in the Southwestern United States.
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| pubmed:affiliation |
Division of Gastroenterology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-5271, USA. mmjamal@salud.unm.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study
|