Linked Life Data

1052786

Source:http://linkedlifedata.com/resource/pubmed/id/1052786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1978-12-29
pubmed:abstractText
Analogues of oxytocin and deaminooxytocin with 4-glutamine replaced by 4-glutamic acid methyl ester readily lose their uterotonic activity when incubated with rat serum, presumably by hydrolysis to the much less active 4-glutamic acid derivatives. On the other hand, inactivation of the deaminooxytocin analogue in the rat uterus, as demonstrated by the "oil-bath" technique, is only slightly more rapid than that of deaminooxytocin and distinctly slower than that of oxytocin. Its in situ/in vitro ratio of uterotonic activity is less than 0.1 whereas that for deaminooxytocin is about 3 and also the peristence of the uterotonic effect in situ is slightly less than that of deaminooxytocin. The results with these "rapidly inactivated" analogues can be used as proof of some predictions of the three-compartment model for tissue distribution of neurohypophysial hormones and its influence upon the time course of a biological response published earlier. The potential use of analogues of neurohypophysial hormones as probes for inactivation mechanisms and the results thus far obtained are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-0664
pubmed:author
pubmed:issnType
Print
pubmed:volume
5 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73S-84S
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Modes of inactivation of neurohypophysial hormones: significance of plasma disappearance rate for their physiological responses.
pubmed:publicationType
Journal Article, In Vitro