Source:http://linkedlifedata.com/resource/pubmed/id/10484360
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3 Pt 1
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pubmed:dateCreated |
1999-10-28
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pubmed:abstractText |
The intravenous glucose tolerance test (IVGTT) single-compartment minimal model (1CMM) method has recently been shown to overestimate glucose effectiveness and underestimate insulin sensitivity. Undermodeling, i.e., use of single- instead of two-compartment description of glucose kinetics, has been advocated to explain these limitations. We describe a new two-compartment minimal model (2CMM) into which we incorporate certain available knowledge on glucose kinetics. 2CMM is numerically identified using a Bayesian approach. Twenty-two standard IVGTT (0.30 g/kg) in normal humans were analyzed. In six subjects, the clamp-based index of insulin sensitivity (ScI) was also measured. 2CMM glucose effectiveness (S2G) and insulin sensitivity (S2I) were, respectively, 60% lower (P < 0.0001) and 35% higher (P < 0.0001) than the corresponding 1CMM S1G and S1I indexes: 2.81 +/- 0.29 (SE) vs. S1G = 4.27 +/- 0.33 ml. min(-1). kg(-1) and S2I = 11.67 +/- 1.71 vs. S1I = 8.68 +/- 1.62 10(2) ml. min(-1). kg(-1) per microU/ml. S2I was not different from ScI = 12.61 +/- 2.13 10(2) ml. min(-1). kg(-1) per microU/ml (nonsignificant), whereas S1I was 60% lower (P < 0.02). In conclusion, a new 2CMM has been presented that improves the accuracy of glucose effectiveness and insulin sensitivity estimates of the classic 1CMM from a standard IVGTT in normal humans.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
E481-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10484360-Adult,
pubmed-meshheading:10484360-Bayes Theorem,
pubmed-meshheading:10484360-Glucose,
pubmed-meshheading:10484360-Glucose Tolerance Test,
pubmed-meshheading:10484360-Humans,
pubmed-meshheading:10484360-Insulin Resistance,
pubmed-meshheading:10484360-Kinetics,
pubmed-meshheading:10484360-Models, Biological,
pubmed-meshheading:10484360-Reference Values
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pubmed:year |
1999
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pubmed:articleTitle |
Minimal model SG overestimation and SI underestimation: improved accuracy by a Bayesian two-compartment model.
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pubmed:affiliation |
Department of Electronics and Informatics, University of Padova, 35131 Padova, Italy. cobelli@dei.unipd.it
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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