|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004927,
umls-concept:C0007113,
umls-concept:C0013216,
umls-concept:C0016360,
umls-concept:C0023413,
umls-concept:C0030705,
umls-concept:C0032790,
umls-concept:C0034656,
umls-concept:C0282461,
umls-concept:C0521115,
umls-concept:C0679729,
umls-concept:C0851346,
umls-concept:C1511237,
umls-concept:C1518578,
umls-concept:C1524062,
umls-concept:C1550436,
umls-concept:C1705509
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1999-10-8
|
|
pubmed:abstractText |
Randomized studies have shown that postoperative chemotherapy with or without radiation therapy (RT) improved local control and survival of patients with stages II or III rectal cancer. However, the optimal sequence of treatments and the optimal chemotherapeutic regimen have not been defined. Modulation of fluorouracil (FU) by leucovorin (LV) has yielded a highly significant difference in response rate from that of FU monotherapy, as suggested by an overview of randomized trials in patients with advanced colorectal cancer. However, this difference in response rate did not translate into a survival benefit.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0923-7534
|
|
pubmed:author |
pubmed-author:AthanassiouEE,
pubmed-author:BasdanisGG,
pubmed-author:BriasoulisEE,
pubmed-author:DafniUU,
pubmed-author:DervenisCC,
pubmed-author:DombrosNN,
pubmed-author:FountzilasGG,
pubmed-author:GamvrosOO,
pubmed-author:HatzitheoharisGG,
pubmed-author:KappasAA,
pubmed-author:KonstantarasCC,
pubmed-author:KosmidisPP,
pubmed-author:LiarosAA,
pubmed-author:PavlidisNN,
pubmed-author:SamantasEE,
pubmed-author:SkarlosDD,
pubmed-author:SouparisAA,
pubmed-author:ZisiadisAA
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
671-6
|
|
pubmed:dateRevised |
2006-4-24
|
|
pubmed:meshHeading |
pubmed-meshheading:10442189-Adult,
pubmed-meshheading:10442189-Aged,
pubmed-meshheading:10442189-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:10442189-Combined Modality Therapy,
pubmed-meshheading:10442189-Drug Administration Schedule,
pubmed-meshheading:10442189-Female,
pubmed-meshheading:10442189-Fluorouracil,
pubmed-meshheading:10442189-Humans,
pubmed-meshheading:10442189-Injections, Intravenous,
pubmed-meshheading:10442189-Leucovorin,
pubmed-meshheading:10442189-Male,
pubmed-meshheading:10442189-Middle Aged,
pubmed-meshheading:10442189-Rectal Neoplasms,
pubmed-meshheading:10442189-Survival Analysis,
pubmed-meshheading:10442189-Treatment Outcome
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Postoperative radiation and concomitant bolus fluorouracil with or without additional chemotherapy with fluorouracil and high-dose leucovorin in patients with high-risk rectal cancer: a randomized phase III study conducted by the Hellenic Cooperative Oncology Group.
|
|
pubmed:affiliation |
Aristotle University of Thessaloniki Medical School, Greece. hecogoff@otenet.gr
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Multicenter Study,
Clinical Trial, Phase III
|
