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rdf:type |
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lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0007634,
umls-concept:C0013138,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0086418,
umls-concept:C0204727,
umls-concept:C0205409,
umls-concept:C0258286,
umls-concept:C1171362,
umls-concept:C1334043,
umls-concept:C1515670,
umls-concept:C1516044,
umls-concept:C1879547
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pubmed:issue |
3
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pubmed:dateCreated |
1999-9-9
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pubmed:databankReference |
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pubmed:abstractText |
Inactivation of the p53 tumor suppressor protein has been observed in a large number of human cancers. Overexpression of p53 induces either growth arrest or programmed cell death (apoptosis). The growth arrest function of p53 is mediated by induction of p21 (WAF1/CIP1), but the mechanisms underlying p53-dependent apoptosis are still largely unknown. To investigate these mechanisms, we have identified six differentially expressed transcripts in a human colon cancer cell line undergoing p53-dependent apoptosis. One of the p53-responsive genes showed significant homology to Drosophila peroxidasin, an extracellular matrix-associated peroxidase, and is likely to be its human homologue. Our results suggest a possible connection between p53-dependent apoptosis and the production of reactive oxygen species.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
261
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
864-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10441517-Amino Acid Sequence,
pubmed-meshheading:10441517-Animals,
pubmed-meshheading:10441517-Apoptosis,
pubmed-meshheading:10441517-Colonic Neoplasms,
pubmed-meshheading:10441517-DNA, Complementary,
pubmed-meshheading:10441517-Drosophila,
pubmed-meshheading:10441517-Extracellular Matrix Proteins,
pubmed-meshheading:10441517-Gene Expression,
pubmed-meshheading:10441517-Genes, p53,
pubmed-meshheading:10441517-Humans,
pubmed-meshheading:10441517-Molecular Sequence Data,
pubmed-meshheading:10441517-Organ Specificity,
pubmed-meshheading:10441517-Peroxidase,
pubmed-meshheading:10441517-Proteins,
pubmed-meshheading:10441517-RNA, Messenger,
pubmed-meshheading:10441517-Rats,
pubmed-meshheading:10441517-Reactive Oxygen Species,
pubmed-meshheading:10441517-Sequence Homology,
pubmed-meshheading:10441517-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene.
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pubmed:affiliation |
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02115, USA. nhorikos@caregroup.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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