Linked Life Data

10424356

Source:http://linkedlifedata.com/resource/pubmed/id/10424356

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-9-9
pubmed:abstractText
Despite extensive studies over many years. there is still no real consensus regarding the mechanisms responsible for hypoxic pulmonary vasoconstriction (HPV). This is partially related to extensive variation between preparations, species, and the length of the hypoxic challenge, but also to an apparent abundance of potential mechanisms. Whereas there is good evidence that hypoxia causes inhibition of K channels in pulmonary artery smooth muscle, with subsequent depolarisation and Ca2+ influx through voltage-activated Ca2+ channels, there is also strong support for a critical role for Ca2+ release from intracellular stores. Moreover other studies suggest that the endothelium provides an essential component of the overall response. We suggest in this review that sustained HPV, as seen in the intact animal, is multi-factorial in origin and requires activation of more than one process for the full response to develop. Fundamental issues that remain unresolved are outlined.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0034-5687
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-71
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Mechanisms of hypoxic pulmonary vasoconstriction: can anyone be right?
pubmed:affiliation
Department of Respiratory Medicine and Allergy, Guy's Hospital Medical and Dental School, King's College London, UK. jeremy.ward@kcl.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't