Linked Life Data

10415541

Source:http://linkedlifedata.com/resource/pubmed/id/10415541

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-8-3
pubmed:abstractText
Intrinsic to the development of new myoprotective protocols for use in cardiac surgery are the requirements of new protocols to be equal to or better than conventional cardioplegia in providing for enhanced post-ischemic functional recovery and decreased myocardial infarct size. Our data suggest that adenosine-enhanced ischemic preconditioning, in which a bolus injection of adenosine to the myocardium is used coincident with ischemic preconditioning, meets these requirements, providing equal cardioprotection as that of cold blood cardioplegia, significantly decreasing myocardial infarct size and significantly enhancing post-ischemic myocardial functional recovery in both the isolated perfused rabbit heart and in the in situ blood-perfused sheep heart. These results further suggest that adenosine-enhanced ischemic preconditioning may provide an effective, alternative myocardial protective protocol to reduce the morbidity and mortality in cardiac surgery.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
874
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-305
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Alternatives for myocardial protection: adenosine-enhanced ischemic preconditioning.
pubmed:affiliation
Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't