10415157

Source:http://linkedlifedata.com/resource/pubmed/id/10415157

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004112, umls-concept:C0205217, umls-concept:C0289174, umls-concept:C0597360, umls-concept:C0870432, umls-concept:C1442792, umls-concept:C1521733, umls-concept:C1555465, umls-concept:C1705417, umls-concept:C1879547
pubmed:issue	2
pubmed:dateCreated	1999-8-24
pubmed:abstractText	In human brain tissues from patients dying with cerebral infarction, hypertensive encephalopathy, Alzheimer's disease, Huntington's disease, frontotemporal dementia, and Creutzfeldt-Jakob disease there is an activation of astrocytes. Such activated astrocytes display GFAP and strong 5-HT(2A), but not 5-HT(2B) or 5-HT(2C), receptor immunoreactivity; this 5-HT(2A) reaction has not been observed in normal, nonactivated astrocytes. It is suggested that an up-regulation of 5-HT(2A) receptors may be part of an early response reaction in astrocytes, possibly designed to maintain homeostasis or to induce secondary message pathways involving trophic factors or glycogenolysis.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0370712
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2A, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2B, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2C, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0014-4886
pubmed:author	pubmed-author:DiabAA, pubmed-author:KumarSS, pubmed-author:MannD MDM, pubmed-author:SinghS KSK, pubmed-author:WuCC
pubmed:copyrightInfo	Copyright 1999 Academic Press.
pubmed:issnType	Print
pubmed:volume	158
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	529-33
pubmed:dateRevised	2009-9-29
pubmed:meshHeading	pubmed-meshheading:10415157-Aged, pubmed-meshheading:10415157-Alzheimer Disease, pubmed-meshheading:10415157-Astrocytes, pubmed-meshheading:10415157-Brain, pubmed-meshheading:10415157-Brain Diseases, pubmed-meshheading:10415157-Caudate Nucleus, pubmed-meshheading:10415157-Cerebrovascular Disorders, pubmed-meshheading:10415157-Creutzfeldt-Jakob Syndrome, pubmed-meshheading:10415157-Frontal Lobe, pubmed-meshheading:10415157-Glial Fibrillary Acidic Protein, pubmed-meshheading:10415157-Humans, pubmed-meshheading:10415157-Middle Aged, pubmed-meshheading:10415157-Receptor, Serotonin, 5-HT2A, pubmed-meshheading:10415157-Receptor, Serotonin, 5-HT2B, pubmed-meshheading:10415157-Receptor, Serotonin, 5-HT2C, pubmed-meshheading:10415157-Receptors, Serotonin, pubmed-meshheading:10415157-Reference Values, pubmed-meshheading:10415157-Up-Regulation
pubmed:year	1999
pubmed:articleTitle	Activated astrocytes display increased 5-HT2a receptor expression in pathological states.
pubmed:affiliation	Department of Pathological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't