| pubmed-article:10400769 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10400769 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:10400769 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:10400769 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:10400769 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10400769 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10400769 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:10400769 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10400769 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10400769 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:10400769 | pubmed:dateCreated | 1999-8-24 | lld:pubmed |
| pubmed-article:10400769 | pubmed:abstractText | Cellular immune responses are thought to be an important antiviral host defense, but the relationship between virus-specific T-helper and cytotoxic-T-lymphocyte (CTL) responses has not been defined. To investigate a potential link between these responses, we examined functional human immunodeficiency virus type 1 (HIV-1)-specific memory CTL precursor frequencies and p24-specific proliferative responses in a cohort of infected untreated persons with a wide range of viral loads and CD4 cell counts. Levels of p24-specific proliferative responses positively correlated with levels of Gag-specific CTL precursors and negatively correlated with levels of plasma HIV-1 RNA. These data linking the levels of HIV-specific CTL with virus-specific helper cell function during chronic viral infection provide cellular immunologic parameters to guide therapeutic and prophylactic vaccine development. | lld:pubmed |
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| pubmed-article:10400769 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10400769 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10400769 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10400769 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10400769 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10400769 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:10400769 | pubmed:author | pubmed-author:RosenbergE... | lld:pubmed |
| pubmed-article:10400769 | pubmed:author | pubmed-author:BillingsleyJ... | lld:pubmed |
| pubmed-article:10400769 | pubmed:author | pubmed-author:JonesN GNG | lld:pubmed |
| pubmed-article:10400769 | pubmed:author | pubmed-author:ColbertD SDS | lld:pubmed |
| pubmed-article:10400769 | pubmed:author | pubmed-author:WalkerB DBD | lld:pubmed |
| pubmed-article:10400769 | pubmed:author | pubmed-author:BuchbinderS... | lld:pubmed |
| pubmed-article:10400769 | pubmed:author | pubmed-author:KalamsS ASA | lld:pubmed |
| pubmed-article:10400769 | pubmed:author | pubmed-author:TrochaA KAK | lld:pubmed |
| pubmed-article:10400769 | pubmed:author | pubmed-author:SheaA KAK | lld:pubmed |
| pubmed-article:10400769 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10400769 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:10400769 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10400769 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10400769 | pubmed:pagination | 6715-20 | lld:pubmed |
| pubmed-article:10400769 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10400769 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10400769 | pubmed:articleTitle | Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection. | lld:pubmed |
| pubmed-article:10400769 | pubmed:affiliation | Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA. kalams@helix.mgh.harvard.edu | lld:pubmed |
| pubmed-article:10400769 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10400769 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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