Source:http://linkedlifedata.com/resource/pubmed/id/10400139
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1999-8-24
|
| pubmed:abstractText |
Studies have shown the important roles of several regulatory and proinflammatory cytokines in insulin-dependent diabetes mellitus (IDDM). CC-chemokine receptors CCR2 and CCR5 bind chemokines that are involved in the trafficking of leukocytes in both basal and inflammatory states. A common 32-bp deletion mutation in the CCR5 gene (CCR5delta32) and a G-to-A nucleotide substitution in the CCR2 at position 190 (CCR2-64I) have recently been described. In the present study, we have determined the frequency of the CCR5delta32 and CCR2-64I alleles in children with IDDM [n = 115; age 1-14 (9.3+/-4.3) y] and in nondiabetic subjects [n = 280; age 1-14 (8.5+/-4.5) y]. The CCR5delta32 allele frequencies were 0.117 in children with IDDM and 0.111 in nondiabetic subjects, indicating that the deletion allele has no association with IDDM. The CCR2-64I allele frequency in children with IDDM was 0.226, which differed significantly from the allele frequency in controls (0.114, p = 0.001). The role of this mutation in IDDM cannot be explained yet, but, because CCR2 mediates the chemotaxis of CD4+ and CD8+ T cells to areas of inflammation and because these cells play important roles in insulitis, a mutation in the CCR2 gene may contribute to the susceptibility to the disease. Alternatively, the 64I allele could be a marker of a linked mutation through linkage disequilibrium. According to these results, the CCR2 gene may be a new candidate for the susceptibility locus of IDDM. However, because no IDDM locus has been identified near 3p21 until now, further investigations are needed to confirm this statement.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0031-3998
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
82-4
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10400139-Adolescent,
pubmed-meshheading:10400139-Age of Onset,
pubmed-meshheading:10400139-Alleles,
pubmed-meshheading:10400139-Child,
pubmed-meshheading:10400139-Child, Preschool,
pubmed-meshheading:10400139-Diabetes Mellitus, Type 1,
pubmed-meshheading:10400139-Female,
pubmed-meshheading:10400139-Genotype,
pubmed-meshheading:10400139-Humans,
pubmed-meshheading:10400139-Infant,
pubmed-meshheading:10400139-Male,
pubmed-meshheading:10400139-Point Mutation,
pubmed-meshheading:10400139-Polymorphism, Genetic,
pubmed-meshheading:10400139-Receptors, CCR2,
pubmed-meshheading:10400139-Receptors, CCR5,
pubmed-meshheading:10400139-Receptors, Chemokine,
pubmed-meshheading:10400139-Receptors, Cytokine,
pubmed-meshheading:10400139-Reference Values,
pubmed-meshheading:10400139-Sequence Deletion
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Chemokine receptor CCR2 and CCR5 polymorphisms in children with insulin-dependent diabetes mellitus.
|
| pubmed:affiliation |
Heim Pál Pediatric Hospital, Budapest, Hungary.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|