| pubmed-article:10382738 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10382738 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10382738 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:10382738 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
| pubmed-article:10382738 | lifeskim:mentions | umls-concept:C1513095 | lld:lifeskim |
| pubmed-article:10382738 | lifeskim:mentions | umls-concept:C0019721 | lld:lifeskim |
| pubmed-article:10382738 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10382738 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10382738 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:10382738 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:10382738 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10382738 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10382738 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10382738 | pubmed:dateCreated | 1999-7-8 | lld:pubmed |
| pubmed-article:10382738 | pubmed:abstractText | IL-12 enhances cytolytic activity and proliferation of NK and T cells, and induces cytokines such as IFN-gamma. No direct effects on non-hematopoietic cells have been shown. This study investigates the effects of IL-12 on melanoma cells in vitro. We analyzed 15 melanoma cell cultures and 1 melanoma cell line. Out of 16 samples 13 expressed the beta chain of the IL-12 receptor (IL-12Rbeta). Preincubation with IL-12 increased the surface levels of human leukocyte antigen (HLA) class I, HLA class II and intercellular adhesion molecule (ICAM)-1 of those cultures with IL-12Rbeta expression. The effects of IL-12 on HLA class I could be blocked by an IL-12-neutralizing monoclonal antibody (mAb), but not by an mAb against IFN-gamma. Melanoma cells transduced with IL-12 expressed enhanced levels of HLA class I, HLA class II and ICAM-1 compared to controls. Co-incubation of the melanoma cells with allogeneic peripheral blood mononuclear cells (PBMC) resulted in enhanced proliferation and increased production of IL-2 and IFN-gamma after pretreatment with IL-12. IL-12 pretreatment increased the susceptibility of melanoma cells to lysis by prestimulated autologous PBMC. Since IL-12 induced immunocritical surface molecules on melanoma cells, it might be beneficial during immune interventions in melanoma patients. | lld:pubmed |
| pubmed-article:10382738 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10382738 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10382738 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10382738 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10382738 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:10382738 | pubmed:author | pubmed-author:AVISK EKE | lld:pubmed |
| pubmed-article:10382738 | pubmed:author | pubmed-author:LaineEE | lld:pubmed |
| pubmed-article:10382738 | pubmed:author | pubmed-author:PavlovicJJ | lld:pubmed |
| pubmed-article:10382738 | pubmed:author | pubmed-author:GeertsenRR | lld:pubmed |
| pubmed-article:10382738 | pubmed:author | pubmed-author:HemmiSS | lld:pubmed |
| pubmed-article:10382738 | pubmed:author | pubmed-author:DummerRR | lld:pubmed |
| pubmed-article:10382738 | pubmed:author | pubmed-author:SeoH CHC | lld:pubmed |
| pubmed-article:10382738 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10382738 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:10382738 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10382738 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10382738 | pubmed:pagination | 1762-73 | lld:pubmed |
| pubmed-article:10382738 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10382738 | pubmed:meshHeading | pubmed-meshheading:10382738... | lld:pubmed |
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| pubmed-article:10382738 | pubmed:meshHeading | pubmed-meshheading:10382738... | lld:pubmed |
| pubmed-article:10382738 | pubmed:meshHeading | pubmed-meshheading:10382738... | lld:pubmed |
| pubmed-article:10382738 | pubmed:meshHeading | pubmed-meshheading:10382738... | lld:pubmed |
| pubmed-article:10382738 | pubmed:meshHeading | pubmed-meshheading:10382738... | lld:pubmed |
| pubmed-article:10382738 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10382738 | pubmed:articleTitle | IL-12 directly up-regulates the expression of HLA class I, HLA class II and ICAM-1 on human melanoma cells: a mechanism for its antitumor activity? | lld:pubmed |
| pubmed-article:10382738 | pubmed:affiliation | Department of Dermatology, University of Zürich Medical School, Switzerland. | lld:pubmed |
| pubmed-article:10382738 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10382738 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10382738 | lld:pubmed |
