Source:http://linkedlifedata.com/resource/pubmed/id/10360778
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1999-6-24
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pubmed:abstractText |
A novel phenotype of familial Creutzfeldt-Jakob disease (CJD) with mutated codon 200 of the prion protein gene (PRNP) coupled with the valine codon 129 (E200K-129V haplotype) has two features never observed in subjects carrying the pathogenic mutation coupled with the methionine codon 129 (E200K-129M haplotype): (1) plaque-like prion protein (PrP) deposits in the cerebellum and (2) type 2 protease-resistant prion protein (PrP(res)). This observation further underlines the role of codon 129 on the mutated PRNP allele in modulating the phenotype of familial prion diseases.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0364-5134
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
812-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10360778-Aged,
pubmed-meshheading:10360778-Blotting, Western,
pubmed-meshheading:10360778-Creutzfeldt-Jakob Syndrome,
pubmed-meshheading:10360778-Female,
pubmed-meshheading:10360778-Genotype,
pubmed-meshheading:10360778-Humans,
pubmed-meshheading:10360778-Mutation,
pubmed-meshheading:10360778-Pedigree,
pubmed-meshheading:10360778-Phenotype,
pubmed-meshheading:10360778-Prions,
pubmed-meshheading:10360778-Valine
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pubmed:year |
1999
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pubmed:articleTitle |
A novel phenotype in familial Creutzfeldt-Jakob disease: prion protein gene E200K mutation coupled with valine at codon 129 and type 2 protease-resistant prion protein.
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pubmed:affiliation |
Institute of Neurology, University of Vienna, and the Austrian Reference Center for Human Prion Diseases.
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pubmed:publicationType |
Journal Article,
Case Reports
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