| pubmed-article:10228082 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10228082 | lifeskim:mentions | umls-concept:C0025295 | lld:lifeskim |
| pubmed-article:10228082 | lifeskim:mentions | umls-concept:C0035608 | lld:lifeskim |
| pubmed-article:10228082 | lifeskim:mentions | umls-concept:C0026565 | lld:lifeskim |
| pubmed-article:10228082 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:10228082 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:10228082 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10228082 | pubmed:dateCreated | 1999-6-21 | lld:pubmed |
| pubmed-article:10228082 | pubmed:abstractText | Compared with beta-lactam antibiotics, rifampin releases smaller quantities of proinflammatory cell wall products from Streptococcus pneumoniae in vitro. Mice infected intracerebrally with S. pneumoniae were treated subcutaneously with 2-mg doses of rifampin or ceftriaxone (n=43 each) every 12 h for 3 days and then observed for another 3 days. Rifampin reduced overall mortality from 49% to 26% (P=.04). Kaplan-Meyer analysis revealed a substantial reduction of mortality during the first 24 h in mice receiving rifampin (difference in survival time: P=.007). Eight h after receiving a single 2-mg dose of rifampin or ceftriaxone, rifampin-treated mice had lower serum and cerebrospinal fluid concentrations of lipoteichoic and teichoic acids than did ceftriaxone-treated mice (median serum level: <0.5 vs. 27.0 ng/mL, P=.02; median cerebrospinal fluid level of pooled specimens: 97.5 vs. 206.0 ng/mL). Thus, the use of rifampin appears promising for reducing the release of proinflammatory bacterial components and decreasing early mortality in bacterial meningitis. | lld:pubmed |
| pubmed-article:10228082 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10228082 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10228082 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10228082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10228082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10228082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10228082 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10228082 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10228082 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:10228082 | pubmed:author | pubmed-author:SchmidtHH | lld:pubmed |
| pubmed-article:10228082 | pubmed:author | pubmed-author:GerberJJ | lld:pubmed |
| pubmed-article:10228082 | pubmed:author | pubmed-author:KochKK | lld:pubmed |
| pubmed-article:10228082 | pubmed:author | pubmed-author:SchneiderOO | lld:pubmed |
| pubmed-article:10228082 | pubmed:author | pubmed-author:SotoAA | lld:pubmed |
| pubmed-article:10228082 | pubmed:author | pubmed-author:BrückWW | lld:pubmed |
| pubmed-article:10228082 | pubmed:author | pubmed-author:MichelUU | lld:pubmed |
| pubmed-article:10228082 | pubmed:author | pubmed-author:NauRR | lld:pubmed |
| pubmed-article:10228082 | pubmed:author | pubmed-author:WellmerAA | lld:pubmed |
| pubmed-article:10228082 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10228082 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:10228082 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10228082 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10228082 | pubmed:pagination | 1557-60 | lld:pubmed |
| pubmed-article:10228082 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10228082 | pubmed:meshHeading | pubmed-meshheading:10228082... | lld:pubmed |
| pubmed-article:10228082 | pubmed:meshHeading | pubmed-meshheading:10228082... | lld:pubmed |
| pubmed-article:10228082 | pubmed:meshHeading | pubmed-meshheading:10228082... | lld:pubmed |
| pubmed-article:10228082 | pubmed:meshHeading | pubmed-meshheading:10228082... | lld:pubmed |
| pubmed-article:10228082 | pubmed:meshHeading | pubmed-meshheading:10228082... | lld:pubmed |
| pubmed-article:10228082 | pubmed:meshHeading | pubmed-meshheading:10228082... | lld:pubmed |
| pubmed-article:10228082 | pubmed:meshHeading | pubmed-meshheading:10228082... | lld:pubmed |
| pubmed-article:10228082 | pubmed:meshHeading | pubmed-meshheading:10228082... | lld:pubmed |
| pubmed-article:10228082 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10228082 | pubmed:articleTitle | Rifampin reduces early mortality in experimental Streptococcus pneumoniae meningitis. | lld:pubmed |
| pubmed-article:10228082 | pubmed:affiliation | Neurologische Universitätsklinik, D-37075 Göttingen, Germany. rnau@gwdg.de | lld:pubmed |
| pubmed-article:10228082 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10228082 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10228082 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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