| pubmed-article:10228051 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10228051 | lifeskim:mentions | umls-concept:C0035236 | lld:lifeskim |
| pubmed-article:10228051 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:10228051 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:10228051 | lifeskim:mentions | umls-concept:C1858460 | lld:lifeskim |
| pubmed-article:10228051 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:10228051 | lifeskim:mentions | umls-concept:C1522673 | lld:lifeskim |
| pubmed-article:10228051 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:10228051 | lifeskim:mentions | umls-concept:C1175000 | lld:lifeskim |
| pubmed-article:10228051 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10228051 | pubmed:dateCreated | 1999-6-21 | lld:pubmed |
| pubmed-article:10228051 | pubmed:abstractText | Alum-adsorbed BBG2Na, a recombinant vaccine derived in part from the respiratory syncytial virus (RSV) subgroup A G protein, induced moderate antibody titers after 1 immunization in 1-week-old mice but conferred complete lung protection upon RSV challenge. The anti-BBG2Na IgG1-IgG2a neonatal isotype profile was suggestive of dominant Th2 responses compared with those in adults. Formulation of BBG2Na with a Th1-driving adjuvant efficiently shifted neonatal responses toward a more balanced and adultlike IgG1-IgG2a profile without compromising its protective efficacy. BBG2Na-induced protective immunity was maintained even after early life immunization in the presence of high titers of maternal antibodies. Under these conditions, the protective efficacy (86%-100%) reflected the high capacity of the nonglycosylated G2Na immunogen to escape inhibition by RSV-A-induced maternal antibodies. Thus, immunization with BBG2Na protected against viral challenge despite neonatal immunologic immaturity and the presence of maternal antibodies, two major obstacles to neonatal RSV vaccine development. | lld:pubmed |
| pubmed-article:10228051 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10228051 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10228051 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10228051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10228051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10228051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10228051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10228051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10228051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10228051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10228051 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10228051 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10228051 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:10228051 | pubmed:author | pubmed-author:LambertP HPH | lld:pubmed |
| pubmed-article:10228051 | pubmed:author | pubmed-author:BernerRR | lld:pubmed |
| pubmed-article:10228051 | pubmed:author | pubmed-author:CórdovaMM | lld:pubmed |
| pubmed-article:10228051 | pubmed:author | pubmed-author:BonnefoyJ YJY | lld:pubmed |
| pubmed-article:10228051 | pubmed:author | pubmed-author:PowerU FUF | lld:pubmed |
| pubmed-article:10228051 | pubmed:author | pubmed-author:NguyenT NTN | lld:pubmed |
| pubmed-article:10228051 | pubmed:author | pubmed-author:SiegristC ACA | lld:pubmed |
| pubmed-article:10228051 | pubmed:author | pubmed-author:Plotnicky-Gil... | lld:pubmed |
| pubmed-article:10228051 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10228051 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:10228051 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10228051 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10228051 | pubmed:pagination | 1326-33 | lld:pubmed |
| pubmed-article:10228051 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10228051 | pubmed:meshHeading | pubmed-meshheading:10228051... | lld:pubmed |
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| pubmed-article:10228051 | pubmed:meshHeading | pubmed-meshheading:10228051... | lld:pubmed |
| pubmed-article:10228051 | pubmed:meshHeading | pubmed-meshheading:10228051... | lld:pubmed |
| pubmed-article:10228051 | pubmed:meshHeading | pubmed-meshheading:10228051... | lld:pubmed |
| pubmed-article:10228051 | pubmed:meshHeading | pubmed-meshheading:10228051... | lld:pubmed |
| pubmed-article:10228051 | pubmed:meshHeading | pubmed-meshheading:10228051... | lld:pubmed |
| pubmed-article:10228051 | pubmed:meshHeading | pubmed-meshheading:10228051... | lld:pubmed |
| pubmed-article:10228051 | pubmed:meshHeading | pubmed-meshheading:10228051... | lld:pubmed |
| pubmed-article:10228051 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10228051 | pubmed:articleTitle | Protective efficacy against respiratory syncytial virus following murine neonatal immunization with BBG2Na vaccine: influence of adjuvants and maternal antibodies. | lld:pubmed |
| pubmed-article:10228051 | pubmed:affiliation | World Health Organization Collaborating Center for Neonatal Vaccinology, University of Geneva, 1211 Geneva 4, Switzerland. siegrist@cmu.unige.ch | lld:pubmed |
| pubmed-article:10228051 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10228051 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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