Source:http://linkedlifedata.com/resource/pubmed/id/10227150
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1999-6-15
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pubmed:abstractText |
Three thiosulfinates were isolated from oil-macerated garlic extract, and their structures were identified as 2-propene-1-sulfinothioic acid S-(Z,E)-1-propenyl ester [AllS(O)SPn-(Z,E)], 2-propenesulfinothioic acid S-methyl ester [AllS(O)SMe], and methanesulfinothioic acid S-(Z,E)-1-propenyl ester [MeS(O)SPn-(Z,E)]. This is the first report of isolating these thiosulfinates from oil-macerated garlic extract. Antimicrobial activities of AllS(O)SPn-(Z,E) and AllS(O)SMe against Gram-positive and negative bacteria and yeasts were compared with 2-propene-1-sulfinothioic acid S-2-propenyl ester [AllS(O)SAll, allicin] which is well-known as the major thiosulfinate in garlic. Antimicrobial activity of AllS(O)SMe and AllS(O)SPn-(Z,E) were comparable and inferior to that of allicin, respectively. This result suggested that the antimicrobial activity of 2-propene sulfinothioic acid S-alk(en)yl esters were affected by alk(en)yl groups. The order for antimicrobial activity was: allyl > or = methyl > propenyl.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0916-8451
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
591-4
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:10227150-Anti-Bacterial Agents,
pubmed-meshheading:10227150-Anti-Infective Agents,
pubmed-meshheading:10227150-Garlic,
pubmed-meshheading:10227150-Gram-Negative Bacteria,
pubmed-meshheading:10227150-Gram-Positive Bacteria,
pubmed-meshheading:10227150-Microbial Sensitivity Tests,
pubmed-meshheading:10227150-Plant Extracts,
pubmed-meshheading:10227150-Plants, Medicinal,
pubmed-meshheading:10227150-Sulfinic Acids,
pubmed-meshheading:10227150-Yeasts
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pubmed:year |
1999
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pubmed:articleTitle |
Antimicrobial activity of the thiosulfinates isolated from oil-macerated garlic extract.
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pubmed:affiliation |
Biodevelopment Division, Nagoya Seiraku Co. Ltd., Aichi, Japan.
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pubmed:publicationType |
Journal Article
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