| pubmed-article:10207053 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10207053 | lifeskim:mentions | umls-concept:C1334090 | lld:lifeskim |
| pubmed-article:10207053 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:10207053 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:10207053 | lifeskim:mentions | umls-concept:C0034818 | lld:lifeskim |
| pubmed-article:10207053 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:10207053 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10207053 | pubmed:dateCreated | 1999-5-18 | lld:pubmed |
| pubmed-article:10207053 | pubmed:abstractText | Insulin-like growth factor II (IGF-II) is a peptide growth factor that is homologous to both insulin-like growth factor I (IGF-I) and insulin and plays an important role in embryonic development and carcinogenesis. IGF-II is believed to mediate its cellular signaling via the transmembrane tyrosine kinase type 1 insulin-like growth factor receptor (IGF-I-R), which is also the receptor for IGF-I. Earlier studies with both cultured cells and transgenic mice, however, have suggested that in the embryo the insulin receptor (IR) may also be a receptor for IGF-II. In most cells and tissues, IR binds IGF-II with relatively low affinity. The IR is expressed in two isoforms (IR-A and IR-B) differing by 12 amino acids due to the alternative splicing of exon 11. In the present study we found that IR-A but not IR-B bound IGF-II with an affinity close to that of insulin. Moreover, IGF-II bound to IR-A with an affinity equal to that of IGF-II binding to the IGF-I-R. Activation of IR-A by insulin led primarily to metabolic effects, whereas activation of IR-A by IGF-II led primarily to mitogenic effects. These differences in the biological effects of IR-A when activated by either IGF-II or insulin were associated with differential recruitment and activation of intracellular substrates. IR-A was preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney and had a relatively increased proportion of isoform A. IR-A expression was also increased in several tumors including those of the breast and colon. These data indicate, therefore, that there are two receptors for IGF-II, both IGF-I-R and IR-A. Further, they suggest that interaction of IGF-II with IR-A may play a role both in fetal growth and cancer biology. | lld:pubmed |
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| pubmed-article:10207053 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10207053 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10207053 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10207053 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10207053 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10207053 | pubmed:month | May | lld:pubmed |
| pubmed-article:10207053 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:10207053 | pubmed:author | pubmed-author:GoldfineI DID | lld:pubmed |
| pubmed-article:10207053 | pubmed:author | pubmed-author:VigneriRR | lld:pubmed |
| pubmed-article:10207053 | pubmed:author | pubmed-author:CostantinoAA | lld:pubmed |
| pubmed-article:10207053 | pubmed:author | pubmed-author:MindtLL | lld:pubmed |
| pubmed-article:10207053 | pubmed:author | pubmed-author:BelfioreAA | lld:pubmed |
| pubmed-article:10207053 | pubmed:author | pubmed-author:ScaliaPP | lld:pubmed |
| pubmed-article:10207053 | pubmed:author | pubmed-author:FrascaFF | lld:pubmed |
| pubmed-article:10207053 | pubmed:author | pubmed-author:PandiniGG | lld:pubmed |
| pubmed-article:10207053 | pubmed:author | pubmed-author:SciaccaLL | lld:pubmed |
| pubmed-article:10207053 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10207053 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:10207053 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10207053 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10207053 | pubmed:pagination | 3278-88 | lld:pubmed |
| pubmed-article:10207053 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:10207053 | pubmed:meshHeading | pubmed-meshheading:10207053... | lld:pubmed |
