Linked Life Data

10171666

Source:http://linkedlifedata.com/resource/pubmed/id/10171666

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-8-26
pubmed:abstractText
The failure of most percutaneous devices (PD) is caused by infection initiated by a lack of a tight seal at the skin-device interface. This interface can be disrupted by both extrinsic and intrinsic forces. Many stress reduction methods have been proposed, the most common being the application of a subcutaneous flange. It is widely believed that the bending compliance of the flange plays a significant role in the success or failure of a PD. A study was conducted to observe the effect of flange compliance on local host response in both a functional and nonfunctional setting. Two PDs having flanges with different bending rigidities were implanted percutaneously in goats (n = 8). After a healing period of 2 weeks, half of these devices were externally stimulated with a random load. All the implants were retrieved after 4 weeks and evaluated histologically. The tissue capsule was significantly thicker and the incidence of severe fibrosis and/or necrosis was higher at the flange rim of the functional implants, irrespective of flange compliance. The more compliant devices were encapsulated with a thick fibrous capsule more frequently than the less compliant ones, irrespective of functional status. The more compliant devices also had a greater incidence of foreign body giant cells in the corner region and elicited severe acute inflammation at the corner and top of the flange more frequently than the less compliant implants.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
T
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1045-4861
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-94
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The influence of flange compliance and mechanical loading on the tissue response to percutaneous devices.
pubmed:affiliation
Department of Bioengineering, Clemson University, South Carolina.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't