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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1999-4-19
pubmed:abstractText
Several recent studies evaluated a possible effect of the prothrombotic polymorphisms such as 5,10 methylenetetrahydrofolate reductase (MTHFR) nt 677C --> T, factor V (F V) nt 1691G --> A (F V Leiden), and factor II (F II) nt 20210 G --> A on the risk of myocardial infarction. In the present study, we analyzed the effect of these prothrombotic polymorphisms, as well as apolipoprotein (Apo) E4, smoking, hypertension, diabetes mellitus, and hypercholesterolemia, on the risk of myocardial infarction in young males. We conducted a case-control study of 112 young males with first acute myocardial infarction (AMI) before the age of 52 and 187 healthy controls of similar age. The prevalences of heterozygotes for F V G1691A and F II G20210A were not significantly different between cases and controls (6.3% v 6.4% and 5.9% v 3.4% among cases and controls, respectively). In contrast, the prevalence of MTHFR 677T homozygosity and the allele frequency of Apo E4 were significantly higher among patients (24.1% v 10.7% and 9.4% v 5.3% among cases and controls, respectively). Concomitant presence of hypertension, hypercholesterolemia, or diabetes and one or more of the four examined polymorphisms increased the risk by almost ninefold (odds ratio [OR] = 8.66; 95% confidence interval [CI], 3.49 to 21.5) and concomitant smoking by almost 18-fold (OR = 17.6; 95% CI, 6.30 to 48.9). When all atherogenic risk factors were analyzed simultaneously by a logistic model, the combination of prothrombotic and Apo E4 polymorphisms with current smoking increased the risk 25-fold (OR = 24.7; 95% CI, 7.17 to 84.9). The presented data suggest a synergistic effect between atherogenic and thrombogenic risk factors in the pathogenesis of AMI, as was recently found in a similar cohort of women.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2186-90
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed-meshheading:10090925-Activated Protein C Resistance, pubmed-meshheading:10090925-Adult, pubmed-meshheading:10090925-Apolipoprotein E4, pubmed-meshheading:10090925-Apolipoproteins E, pubmed-meshheading:10090925-Case-Control Studies, pubmed-meshheading:10090925-Comorbidity, pubmed-meshheading:10090925-Diabetes Mellitus, pubmed-meshheading:10090925-Factor V, pubmed-meshheading:10090925-Gene Frequency, pubmed-meshheading:10090925-Genetic Predisposition to Disease, pubmed-meshheading:10090925-Genotype, pubmed-meshheading:10090925-Humans, pubmed-meshheading:10090925-Hypercholesterolemia, pubmed-meshheading:10090925-Hypertension, pubmed-meshheading:10090925-Logistic Models, pubmed-meshheading:10090925-Male, pubmed-meshheading:10090925-Methylenetetrahydrofolate Reductase (NADPH2), pubmed-meshheading:10090925-Middle Aged, pubmed-meshheading:10090925-Myocardial Infarction, pubmed-meshheading:10090925-Oxidoreductases Acting on CH-NH Group Donors, pubmed-meshheading:10090925-Polymorphism, Genetic, pubmed-meshheading:10090925-Prothrombin, pubmed-meshheading:10090925-Risk Factors, pubmed-meshheading:10090925-Smoking
pubmed:year
1999
pubmed:articleTitle
Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males.
pubmed:affiliation
Institute of Thrombosis and Hemostasis, Department of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel. Zeligson@post.ccsg.tau.ac.il
pubmed:publicationType
Journal Article