Source:http://linkedlifedata.com/resource/pubmed/id/10074939
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1999-3-29
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pubmed:databankReference | |
pubmed:abstractText |
The X-ray crystal structures of the catalytic domain of human collagenase-3 (MMP-13) and collagenase-1 (MMP-1) with bound inhibitors provides a basis for understanding the selectivity profile of a novel series of matrix metalloprotease (MMP) inhibitors. Differences in the relative size and shape of the MMP S1' pockets suggest that this pocket is a critical determinant of MMP inhibitor selectivity. The collagenase-3 S1' pocket is long and open, easily accommodating large P1' groups, such as diphenylether. In contrast, the collagenase-1 S1' pocket must undergo a conformational change to accommodate comparable P1' groups. The selectivity of the diphenylether series of inhibitors for collagenase-3 is largely determined by their affinity for the preformed S1' pocket of collagenase-3, as compared to the induced fit in collagenase-1.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagenases,
http://linkedlifedata.com/resource/pubmed/chemical/MMP13 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 13,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1072-8368
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
217-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10074939-Amino Acid Sequence,
pubmed-meshheading:10074939-Catalytic Domain,
pubmed-meshheading:10074939-Collagenases,
pubmed-meshheading:10074939-Crystallography, X-Ray,
pubmed-meshheading:10074939-Humans,
pubmed-meshheading:10074939-Matrix Metalloproteinase 1,
pubmed-meshheading:10074939-Matrix Metalloproteinase 13,
pubmed-meshheading:10074939-Protease Inhibitors,
pubmed-meshheading:10074939-Protein Structure, Secondary
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pubmed:year |
1999
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pubmed:articleTitle |
Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors.
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pubmed:affiliation |
Inflammatory Diseases Unit, Roche Bioscience, Palo Alto, California 94304, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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