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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-6-18
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pubmed:abstractText |
Sumatriptan is a 5-HT1B/1D-receptor agonist which also has affinity for 5-HT1F-receptors. The vasoconstrictor effects of sumatriptan are thought to be 5-HT1B-receptor mediated and these receptors have been shown to be expressed in human cranial blood vessels. However, in the same tissue mRNA coding for 5-HT1F-receptors has also been identified and this study addresses the possibility of whether 5-HT1F-receptor activation contributes to vasoconstriction.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-1329294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-1565658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-1665260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-1676084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-2158835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-7498311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-7656980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-7679023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-8057272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-8087924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-8394988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-8396718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-8401923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-8584041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-8700126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-8720594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-8741180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-8789380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-9126877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-9170337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-9209774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10073743-9243618
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/GR 127935,
http://linkedlifedata.com/resource/pubmed/chemical/N-(4-methoxy-3-(4-methylpiperazin-1-...,
http://linkedlifedata.com/resource/pubmed/chemical/Oxadiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Sumatriptan
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
75-82
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10073743-Animals,
pubmed-meshheading:10073743-Benzamides,
pubmed-meshheading:10073743-Binding, Competitive,
pubmed-meshheading:10073743-CHO Cells,
pubmed-meshheading:10073743-Cell Line,
pubmed-meshheading:10073743-Cloning, Molecular,
pubmed-meshheading:10073743-Cricetinae,
pubmed-meshheading:10073743-Humans,
pubmed-meshheading:10073743-Meningeal Arteries,
pubmed-meshheading:10073743-Oxadiazoles,
pubmed-meshheading:10073743-Piperazines,
pubmed-meshheading:10073743-Pyridines,
pubmed-meshheading:10073743-RNA, Messenger,
pubmed-meshheading:10073743-Receptors, Serotonin,
pubmed-meshheading:10073743-Serotonin Antagonists,
pubmed-meshheading:10073743-Serotonin Receptor Agonists,
pubmed-meshheading:10073743-Sumatriptan,
pubmed-meshheading:10073743-Vasoconstriction
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pubmed:year |
1999
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pubmed:articleTitle |
Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation.
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pubmed:affiliation |
Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex.
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pubmed:publicationType |
Journal Article,
In Vitro
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