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rdf:type |
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lifeskim:mentions |
umls-concept:C0009506,
umls-concept:C0014597,
umls-concept:C0021853,
umls-concept:C0028778,
umls-concept:C0033268,
umls-concept:C0036720,
umls-concept:C0040669,
umls-concept:C0086418,
umls-concept:C0126732,
umls-concept:C0332206,
umls-concept:C0596988,
umls-concept:C1334877,
umls-concept:C1818972
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pubmed:issue |
1
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pubmed:dateCreated |
1999-3-25
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pubmed:abstractText |
Recent studies suggest that interleukin-1beta (IL-1beta) stimulates the production of the acute phase protein complement component C3 in human intestinal epithelial cells. The transcription factor NF-kappaB activates different genes involved in the response to cytokines. It is not known if IL-1beta-induced C3 production in the enterocyte is regulated by NF-kappaB.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Complement C3,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Genistein,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Leupeptins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Thiocarbamates,
http://linkedlifedata.com/resource/pubmed/chemical/Tosyllysine Chloromethyl Ketone,
http://linkedlifedata.com/resource/pubmed/chemical/acetylleucyl-leucyl-norleucinal,
http://linkedlifedata.com/resource/pubmed/chemical/pyrrolidine dithiocarbamic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-4804
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48-55
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10068525-Base Sequence,
pubmed-meshheading:10068525-Caco-2 Cells,
pubmed-meshheading:10068525-Complement C3,
pubmed-meshheading:10068525-DNA Primers,
pubmed-meshheading:10068525-DNA-Binding Proteins,
pubmed-meshheading:10068525-Genistein,
pubmed-meshheading:10068525-Humans,
pubmed-meshheading:10068525-I-kappa B Proteins,
pubmed-meshheading:10068525-Interleukin-1,
pubmed-meshheading:10068525-Intestinal Mucosa,
pubmed-meshheading:10068525-Leupeptins,
pubmed-meshheading:10068525-Mutation,
pubmed-meshheading:10068525-NF-kappa B,
pubmed-meshheading:10068525-Pyrrolidines,
pubmed-meshheading:10068525-RNA, Messenger,
pubmed-meshheading:10068525-Thiocarbamates,
pubmed-meshheading:10068525-Tosyllysine Chloromethyl Ketone,
pubmed-meshheading:10068525-Transfection
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pubmed:year |
1999
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pubmed:articleTitle |
Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha.
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pubmed:affiliation |
University of Cincinnati Medical Center, Children's Hospital Medical Center, Cincinnati, Ohio, 45267, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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