| pubmed-article:10027876 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10027876 | lifeskim:mentions | umls-concept:C0026650 | lld:lifeskim |
| pubmed-article:10027876 | lifeskim:mentions | umls-concept:C0599779 | lld:lifeskim |
| pubmed-article:10027876 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:10027876 | lifeskim:mentions | umls-concept:C0205494 | lld:lifeskim |
| pubmed-article:10027876 | lifeskim:mentions | umls-concept:C0073379 | lld:lifeskim |
| pubmed-article:10027876 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10027876 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:10027876 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:10027876 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10027876 | pubmed:dateCreated | 1999-4-1 | lld:pubmed |
| pubmed-article:10027876 | pubmed:abstractText | Posthypoxic myoclonus and seizures precipitate as secondary neurological consequences in ischemic/hypoxic insults of the central nervous system. Neuronal hyperexcitation may be due to excessive activation of glutamatergic neurotransmission, an effect that has been shown to follow ischemic/hypoxic events. Therefore, riluzole, an anticonvulsant that inhibits the release of glutamate by stabilizing the inactivated state of activated voltage-sensitive sodium channels, was tested for its antimyoclonic and neuroprotective properties in the cardiac arrest-induced animal model of posthypoxic myoclonus. Riluzole (4-12 mg/kg i.p.) dose-dependently attenuated the audiogenic seizures and action myoclonus seen in this animal model. Histological examination using Nissl staining and the novel Fluoro-Jade histochemistry in cardiac-arrested animals showed an extensive neuronal degeneration in the hippocampus and cerebellum. Riluzole treatment almost completely prevented the neuronal degeneration in these brain areas. The neuroprotective effect was more pronounced in hippocampal pyramidal neurons and cerebellar Purkinje cells. These effects were seen at therapeutically relevant doses of riluzole, and the animals tolerated the treatment well. These findings indicate that the pathogenesis of posthypoxic myoclonus and seizure may involve excessive activation of glutamate neurotransmission, and that riluzole may serve as an effective pharmacological agent with neuroprotective potential for the treatment of neurological conditions associated with cardiac arrest in humans. | lld:pubmed |
| pubmed-article:10027876 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027876 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10027876 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027876 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10027876 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027876 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027876 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027876 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10027876 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10027876 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:10027876 | pubmed:author | pubmed-author:NguyenBB | lld:pubmed |
| pubmed-article:10027876 | pubmed:author | pubmed-author:TenO DOD | lld:pubmed |
| pubmed-article:10027876 | pubmed:author | pubmed-author:TruongD DDD | lld:pubmed |
| pubmed-article:10027876 | pubmed:author | pubmed-author:KanthasamyA... | lld:pubmed |
| pubmed-article:10027876 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10027876 | pubmed:volume | 288 | lld:pubmed |
| pubmed-article:10027876 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10027876 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10027876 | pubmed:pagination | 1340-8 | lld:pubmed |
| pubmed-article:10027876 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10027876 | pubmed:meshHeading | pubmed-meshheading:10027876... | lld:pubmed |
| pubmed-article:10027876 | pubmed:meshHeading | pubmed-meshheading:10027876... | lld:pubmed |
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| pubmed-article:10027876 | pubmed:meshHeading | pubmed-meshheading:10027876... | lld:pubmed |
| pubmed-article:10027876 | pubmed:meshHeading | pubmed-meshheading:10027876... | lld:pubmed |
| pubmed-article:10027876 | pubmed:meshHeading | pubmed-meshheading:10027876... | lld:pubmed |
| pubmed-article:10027876 | pubmed:meshHeading | pubmed-meshheading:10027876... | lld:pubmed |
| pubmed-article:10027876 | pubmed:meshHeading | pubmed-meshheading:10027876... | lld:pubmed |
| pubmed-article:10027876 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10027876 | pubmed:articleTitle | Effect of riluzole on the neurological and neuropathological changes in an animal model of cardiac arrest-induced movement disorder. | lld:pubmed |
| pubmed-article:10027876 | pubmed:affiliation | Parkinson's and Movement Disorders Institute, Long Beach Memorial Medical Center, Long Beach, California 90801-1428, USA. akanthas@uci.edu | lld:pubmed |
| pubmed-article:10027876 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10027876 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10027876 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
