| pubmed-article:10027649 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10027649 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:10027649 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10027649 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10027649 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10027649 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:10027649 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10027649 | pubmed:dateCreated | 1999-8-2 | lld:pubmed |
| pubmed-article:10027649 | pubmed:abstractText | Interferons (IFNs) stimulate gene expression to mediate their biological actions. A multimeric transcription factor consisting of STAT1, STAT2 and p48, a DNA binding protein, regulates IFN-alpha/beta stimulated gene expression. Since the cellular level of p48 is also increased by pre-treatment of cells with IFN-gamma, it is also known as ISGF3gamma. To understand how IFN-gamma regulates the expression of the p48 gene, we have previously isolated and characterized the promoter of murine p48 gene and identified a novel gamma-IFN activated transcriptional element (GATE). In this study using several mutant constructs of p48 promoter we have determined that the same element responds to IFN-alpha/beta treatment. Relatively high doses of IFN-alpha/beta compared to IFN-gamma are required for the induction of p48 promoter. This ability of IFN-alpha/beta to regulate GATE dependent gene expression is linked to the activation of a factor induced by IFN-alpha. However, IFN-gamma induces the binding of two gamma-IFN inducible factors (GIFs) to GATE. The IFN-alpha inducible GATE binding factor is not recognized by specific antibodies raised against the known IFN-regulated factors. It is likely IFN-gamma is a stronger inducer of this gene because it activates two GIFs. GATE-like elements present in hither to undefined IFN-stimulated genes may control IFN-responses in a unique manner. | lld:pubmed |
| pubmed-article:10027649 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10027649 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027649 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10027649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027649 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10027649 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10027649 | pubmed:issn | 0166-3542 | lld:pubmed |
| pubmed-article:10027649 | pubmed:author | pubmed-author:LindRR | lld:pubmed |
| pubmed-article:10027649 | pubmed:author | pubmed-author:KalvakolanuD... | lld:pubmed |
| pubmed-article:10027649 | pubmed:author | pubmed-author:WeihuaXX | lld:pubmed |
| pubmed-article:10027649 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10027649 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:10027649 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10027649 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10027649 | pubmed:pagination | 145-53 | lld:pubmed |
| pubmed-article:10027649 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10027649 | pubmed:meshHeading | pubmed-meshheading:10027649... | lld:pubmed |
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| pubmed-article:10027649 | pubmed:meshHeading | pubmed-meshheading:10027649... | lld:pubmed |
| pubmed-article:10027649 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10027649 | pubmed:articleTitle | Regulation of interferon-alpha/beta-stimulated gene expression through the gamma-activated transcriptional element. | lld:pubmed |
| pubmed-article:10027649 | pubmed:affiliation | Greenebaum Cancer Center, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA. | lld:pubmed |
| pubmed-article:10027649 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10027649 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
