| pubmed-article:10027418 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10027418 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10027418 | lifeskim:mentions | umls-concept:C0014609 | lld:lifeskim |
| pubmed-article:10027418 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:10027418 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10027418 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:10027418 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10027418 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10027418 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10027418 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10027418 | pubmed:dateCreated | 1999-3-4 | lld:pubmed |
| pubmed-article:10027418 | pubmed:abstractText | At the tissue level, there is experimental and clinical data to suggest a cytokinetic coordination of the cell cycle with a greater proportion of cycling cells entering S-phase and mitosis at specific times of the day. The association of certain cell-cycle proteins with defined events in the cell cycle is well established and may be used to study the timing of cell-cycle phases over 24 hours. In this study oral mucosal biopsies were obtained from six normal human volunteers at 4-hour intervals, six times over 24 hours. Using immunohistochemistry, the number of positive cells expressing the proteins p53, cyclin-E, cyclin-A, cyclin-B1, and Ki-67 was determined for each biopsy and expressed as the number of positive cells per mm of basement membrane. We found a statistically significant circadian variation in the nuclear expression of all of these proteins with the high point of expression for p53 at 10:56 hours, cyclin-E at 14:59 hours, cyclin-A at 16:09 hours, cyclin-B1 at 21:13 hours, and Ki-67 at 02:50 hours. The circadian variation in the nuclear expression of cyclins-E (G1/S phase), -A (G2-phase), and -B1 (M-phase) with a normal physiological progression over time suggests a statistically significant circadian variation in oral epithelial cell proliferation. The finding of a circadian variation in the nuclear expression of p53 protein corresponding to late G1 is novel. This information has clinical implications regarding the timing of chemotherapy and radiotherapy. | lld:pubmed |
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| pubmed-article:10027418 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10027418 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10027418 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10027418 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10027418 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10027418 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:10027418 | pubmed:author | pubmed-author:SothernR BRB | lld:pubmed |
| pubmed-article:10027418 | pubmed:author | pubmed-author:JordanR CRC | lld:pubmed |
| pubmed-article:10027418 | pubmed:author | pubmed-author:BjarnasonG... | lld:pubmed |
| pubmed-article:10027418 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10027418 | pubmed:volume | 154 | lld:pubmed |
| pubmed-article:10027418 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10027418 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10027418 | pubmed:pagination | 613-22 | lld:pubmed |
| pubmed-article:10027418 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10027418 | pubmed:meshHeading | pubmed-meshheading:10027418... | lld:pubmed |
| pubmed-article:10027418 | pubmed:meshHeading | pubmed-meshheading:10027418... | lld:pubmed |
| pubmed-article:10027418 | pubmed:meshHeading | pubmed-meshheading:10027418... | lld:pubmed |
| pubmed-article:10027418 | pubmed:meshHeading | pubmed-meshheading:10027418... | lld:pubmed |
| pubmed-article:10027418 | pubmed:meshHeading | pubmed-meshheading:10027418... | lld:pubmed |
| pubmed-article:10027418 | pubmed:meshHeading | pubmed-meshheading:10027418... | lld:pubmed |
| pubmed-article:10027418 | pubmed:meshHeading | pubmed-meshheading:10027418... | lld:pubmed |
| pubmed-article:10027418 | pubmed:meshHeading | pubmed-meshheading:10027418... | lld:pubmed |
| pubmed-article:10027418 | pubmed:meshHeading | pubmed-meshheading:10027418... | lld:pubmed |
| pubmed-article:10027418 | pubmed:meshHeading | pubmed-meshheading:10027418... | lld:pubmed |
| pubmed-article:10027418 | pubmed:meshHeading | pubmed-meshheading:10027418... | lld:pubmed |
| pubmed-article:10027418 | pubmed:meshHeading | pubmed-meshheading:10027418... | lld:pubmed |
| pubmed-article:10027418 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10027418 | pubmed:articleTitle | Circadian variation in the expression of cell-cycle proteins in human oral epithelium. | lld:pubmed |
