{
  "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00983" : {
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/limsDrugId" : [ {
      "value" : "983",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/reference" : [ {
      "value" : "",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/molecularWeightMono" : [ {
      "value" : "344.1736",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/description" : [ {
      "value" : "Formoterol is a long-acting beta2-agonist used in the management of asthma and/or chronic obstructive pulmonary disease (COPD). Inhaled formoterol works like other beta2-agonists, causing bronchodilatation by relaxing the smooth muscle in the airway so as to treat the exacerbation of asthma.",
      "type" : "literal"
    } ],
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "value" : "Formoterol",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/updateDate" : [ {
      "value" : "2008-08-26 14:52:04 UTC",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/interactionInsert" : [ {
      "value" : "http://129.128.185.122/drugbank2/drugs/DB00983/inserts/1920/full",
      "type" : "uri"
    } ],
    "http://xmlns.com/foaf/0.1/page" : [ {
      "value" : "http://dbpedia.org/page/Formoterol",
      "type" : "uri"
    }, {
      "value" : "http://www.drugbank.ca/drugs/DB00983",
      "type" : "uri"
    }, {
      "value" : "http://en.wikipedia.org/wiki/Formoterol",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/possibleDiseaseTarget" : [ {
      "value" : "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/116",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/149",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/851",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/1499",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/1598",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/3413",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/rxlistLink" : [ {
      "value" : "http://www.rxlist.com/cgi/generic/foradil.htm",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/fdaLabelFiles" : [ {
      "value" : "2001-02-01\t/drugs/983/fda_labels/799\n2004-06-01\t/drugs/983/fda_labels/970",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/indication" : [ {
      "value" : "For use as long-term maintenance treatment of asthma in patients 6 years of age and older with reversible obstructive airways disease, including patients with symptoms of nocturnal asthma, who are using optimal corticosteroid treatment and experiencing regular or frequent breakthrough symptoms requiring use of a short-acting bronchodilator.",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/enzyme" : [ {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/enzymes/2",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/enzymes/3",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/enzymes/4",
      "type" : "uri"
    } ],
    "http://linkedlifedata.com/resource/relationontology/hasTarget" : [ {
      "value" : "http://purl.uniprot.org/uniprot/P07550",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/creationDate" : [ {
      "value" : "2005-06-13 13:24:05 UTC",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/brandName" : [ {
      "value" : "Foradil",
      "type" : "literal"
    }, {
      "value" : "Foradile",
      "type" : "literal"
    }, {
      "value" : "Oxeze Turbuhaler",
      "type" : "literal"
    }, {
      "value" : "Oxeze Turbuhaler Foradil",
      "type" : "literal"
    }, {
      "value" : "Oxis",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/predictedWaterSolubility" : [ {
      "value" : "4.16e-02 mg/mL",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/ahfsCode" : [ {
      "value" : "12:12.08.12",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/genericName" : [ {
      "value" : "Formoterol",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/experimentalLogpHydrophobicity" : [ {
      "value" : "2.2",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/smilesStringIsomeric" : [ {
      "value" : "COC1=CC=C(C[C@@H](C)NC[C@@H](O)C2=CC(NC=O)=C(O)C=C2)C=C1",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/predictedLogs" : [ {
      "value" : "-3.92",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/casRegistryNumber" : [ {
      "value" : "http://bio2rdf.org/cas:73573-87-2",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/predictedLogpHydrophobicity" : [ {
      "value" : "1.91",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/target" : [ {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/targets/766",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/state" : [ {
      "value" : "Solid",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/molecularWeightAverage" : [ {
      "value" : "344.4049",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/drugCategory" : [ {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugcategory/adrenergicBeta-agonists",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugcategory/bronchodilatorAgents",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugcategory/sympathomimetic",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/dpdDrugIdNumber" : [ {
      "value" : "02237225",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/experimentalWaterSolubility" : [ {
      "value" : "Slightly (as fumarate salt)",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/toxicity" : [ {
      "value" : "An overdosage is likely to lead to effects that are typical of ß2-adrenergic stimulants: nausea, vomiting, headache, tremor, somnolence, palpitations, tachycardia, ventricular arrhythmias, metabolic acidosis, hypokalemia, hyperglycemia.",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/patientInformationInsert" : [ {
      "value" : "http://129.128.185.122/drugbank2/drugs/DB00983/inserts/140/full",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/proteinBinding" : [ {
      "value" : "The binding of formoterol to human plasma proteins in vitro was 61%-64% at concentrations from 0.1 to 100 ng/mL. Binding to human serum albumin in vitro was 31%-38% over a range of 5 to 500 ng/mL. The concentrations of formoterol used to assess the plasma protein binding were higher than those achieved in plasma following inhalation of a single 120 µg dose.",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/massSpecFile" : [ {
      "value" : "0",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/pharmacology" : [ {
      "value" : "Formoterol is a long-acting selective beta2-adrenergic receptor agonist (beta2-agonist). Inhaled formoterol fumarate acts locally in the lung as a bronchodilator. In vitro studies have shown that formoterol has more than 200-fold greater agonist activity at beta2-receptors than at beta1- receptors. Although beta2-receptors are the predominant adrenergic receptors in bronchial smooth muscle and beta1-receptors are the predominant receptors in the heart, there are also beta2-receptors in the human heart comprising 10%-50% of the total beta-adrenergic receptors. The precise function of these receptors has not been established, but they raise the possibility that even highly selective beta2- agonists may have cardiac effects.",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/pubchemSubstanceId" : [ {
      "value" : "10007",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/msdsFiles" : [ {
      "value" : "/drugs/983/safety_sheets/678",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/affectedOrganism" : [ {
      "value" : "Humans and other mammals",
      "type" : "literal"
    } ],
    "http://linkedlifedata.com/resource/relationontology/treat" : [ {
      "value" : "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/116",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/149",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/851",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/1499",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/1598",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/3413",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/inchiKey" : [ {
      "value" : "BPZSYCZIITTYBL-PKSOQXRJCP",
      "type" : "literal"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#type" : [ {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/vocab/resource/class/Offer",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/drugs",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/smilesStringCanonical" : [ {
      "value" : "COC1=CC=C(CC(C)NCC(O)C2=CC(NC=O)=C(O)C=C2)C=C1",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/dosageForm" : [ {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/dosageforms/aerosolMeteredRespiratory(inhalation)",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/dosageforms/capsuleRespiratory(inhalation)",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/drugType" : [ {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugtype/approved",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugtype/investigational",
      "type" : "uri"
    }, {
      "value" : "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugtype/smallMolecule",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/primaryAccessionNo" : [ {
      "value" : "DB00983",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/inchiIdentifier" : [ {
      "value" : "InChI=1/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)/f/h21H",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/keggCompoundId" : [ {
      "value" : "http://bio2rdf.org/cpd:C07805",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/halfLife" : [ {
      "value" : "10 hours",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/mechanismOfAction" : [ {
      "value" : "The pharmacologic effects of beta2-adrenoceptor agonist drugs, including formoterol, are at least in part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3', 5'-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. In vitro tests show that formoterol is an inhibitor of the release of mast cell mediators, such as histamine and leukotrienes, from the human lung. Formoterol also inhibits histamine-induced plasma albumin extravasation in anesthetized guinea pigs and inhibits allergen-induced eosinophil influx in dogs with airway hyper-responsiveness. The relevance of these in vitro and animal findings to humans is unknown.",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/pubchemCompoundId" : [ {
      "value" : "3410",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/chemicalIupacName" : [ {
      "value" : "N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/synonym" : [ {
      "value" : "formoterol",
      "type" : "literal"
    }, {
      "value" : "Formoterol fumarate",
      "type" : "literal"
    }, {
      "value" : "Formoterolum [INN-Latin]",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/contraindicationInsert" : [ {
      "value" : "http://129.128.185.122/drugbank2/drugs/DB00983/inserts/905/full",
      "type" : "uri"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/chemicalFormula" : [ {
      "value" : "C19H24N2O4",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/atcCode" : [ {
      "value" : "R03AC13",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/structure" : [ {
      "value" : "1",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/biotransformation" : [ {
      "value" : "Metabolized primarily by direct glucuronidation at either the phenolic or aliphatic hydroxyl group and O-demethylation followed by glucuronide conjugation at either phenolic hydroxyl groups. Minor pathways involve sulfate conjugation of formoterol and deformylation followed by sulfate conjugation. The most prominent pathway involves direct conjugation at the phenolic hydroxyl group. The second major pathway involves O-demethylation followed by conjugation at the phenolic 2'-hydroxyl group. Four cytochrome P450 isozymes (CYP2D6, CYP2C19, CYP2C9 and CYP2A6) are involved in the O-demethylation of formoterol.",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/absorption" : [ {
      "value" : "Rapidly absorbed into plasma following administration by oral inhalation. It is likely that the majority of the inhaled formoterol delivered is swallowed and then absorbed from the gastrointestinal tract.",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/secondaryAccessionNumber" : [ {
      "value" : "aprd00641",
      "type" : "literal"
    } ],
    "http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/pharmgkbId" : [ {
      "value" : "PA13468790",
      "type" : "literal"
    } ],
    "http://www.w3.org/2004/02/skos/core#exactMatch" : [ {
      "value" : "http://data.linkedct.org/resource/intervention/5719",
      "type" : "uri"
    }, {
      "value" : "http://data.linkedct.org/resource/intervention/17638",
      "type" : "uri"
    }, {
      "value" : "http://data.linkedct.org/resource/intervention/24015",
      "type" : "uri"
    }, {
      "value" : "http://data.linkedct.org/resource/intervention/37968",
      "type" : "uri"
    }, {
      "value" : "http://www.dbpedia.org/resource/Formoterol",
      "type" : "uri"
    }, {
      "value" : "http://dbpedia.org/resource/Formoterol",
      "type" : "uri"
    }, {
      "value" : "http://data.linkedct.org/resource/intervention/17632",
      "type" : "uri"
    }, {
      "value" : "http://data.linkedct.org/resource/intervention/37966",
      "type" : "uri"
    }, {
      "value" : "http://data.linkedct.org/resource/intervention/44754",
      "type" : "uri"
    }, {
      "value" : "http://data.linkedct.org/resource/intervention/56526",
      "type" : "uri"
    } ]
  }
}