Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/752
Predicate | Object |
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rdf:type | |
rdfs:label |
Sodium Lactate (Injection, Solution)
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dailymed-instance:dosage |
As directed by a
physician. Dosage is dependent upon the age, weight and clinical
condition of the patient as well as laboratory determinations. Parenteral drug
products should be inspected visually for particulate matter and
discoloration prior to administration whenever solution and container
permit. Use of a final filter is recommended during administration of
all parenteral solutions, where possible. All injections in
VIAFLEX plastic containers are intended for intravenous administration
using sterile equipment. Additives may be
incompatible. Complete information is not available. Those additives
known to be incompatible should not be used. Consult with pharmacist, if
available. If, in the informed judgment of the physician, it is deemed
advisable to introduce additives, use aseptic technique. Mix thoroughly
when additives have been introduced. Do not store solutions containing
additives.
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dailymed-instance:descripti... |
Sodium Lactate
Injection, USP (M/6 Sodium Lactate) is a sterile, nonpyrogenic solution
for fluid and electrolyte replenishment and caloric supply in a single
dose container for intravenous administration. It contains no
antimicrobial agents. The pH may have been adjusted with lactic acid.
Composition, osmolarity, pH, ionic concentration and caloric content are
shown in Table 1. The VIAFLEX plastic
container is fabricated from a specially formulated polyvinyl chloride
(PL 146 Plastic). The amount of water that can permeate from inside the
container into the overwrap is insufficient to affect the solution
significantly. Solutions in contact with the plastic container can leach
out certain of its chemical components in very small amounts within the
expiration period, e.g., di-2-ethylhexyl phthalate (DEHP), up to 5 parts
per million. However, the safety of the plastic has been confirmed in
tests in animals according to USP biological tests for plastic
containers as well as by tissue culture toxicity studies.
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dailymed-instance:clinicalP... |
Sodium Lactate
Injection, USP has value as a source of water, electrolytes, and
calories. It is capable of inducing diuresis depending on the clinical
condition of the patient. Sodium Lactate
Injection, USP produces a metabolic alkalinizing effect. Lactate ions
are metabolized ultimately to carbon dioxide and water, which requires
the consumption of hydrogen cations.
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dailymed-instance:activeIng... | |
dailymed-instance:contraind... |
None known
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dailymed-instance:supply |
Sodium Lactate
Injection, USP (M/6 Sodium Lactate) in VIAFLEX plastic container is
available as follows: Exposure of
pharmaceutical products to heat should be minimized. Avoid excessive
heat. It is recommended the product be stored at room temperature
(25��C); brief exposure up to 40��C does not adversely affect the
product.
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dailymed-instance:activeMoi... | |
dailymed-instance:inactiveI... | |
dailymed-instance:precautio... |
Clinical evaluation
and periodic laboratory determinations are necessary to monitor changes
in fluid balance, electrolyte concentrations, and acid base balance
during prolonged parenteral therapy or whenever the condition of the patient warrants such evaluation. Caution must be
exercised in the administration of these injections to patients
receiving corticosteroids or corticotropin.<br/>Pregnancy:<br/>Teratogenic
Effects:<br/>Pediatric Use: Safety and
effectiveness of Sodium Lactate Injection, USP in pediatric
patients have not been established by adequate and well
controlled trials, however, the use of sodium lactate solutions
in the pediatric population is referenced in the medical
literature. The warnings, precautions and adverse reactions
identified in the label copy should be observed in the pediatric
population.<br/>Carcinogenesis,
Mutagenesis, Impairment of Fertility: Studies
with Sodium Lactate Injection, USP have not been performed to
evaluate carcinogenic potential, mutagenic potential, or effects
on fertility.<br/>Nursing Mothers: It is not
known whether this drug is excreted in human milk. Because many
drugs are excreted in human milk, caution should be exercised
when Sodium Lactate Injection, USP is administered to a nursing
mother.<br/>Geriatric Use: Clinical
studies of Sodium Lactate Injection, USP did not include
sufficient numbers of subjects aged 65 and over to determine
whether they respond differently from younger subjects. Other
reported clinical experience has not identified differences in
responses between the elderly and younger patients. In general,
dose selection for an elderly patient should be cautious,
usually starting at the low end of the dosing range, reflecting
the greater frequency of decreased hepatic, renal, or cardiac
function, and of concomitant disease or drug therapy. Do not
administer unless solution is clear and seal is
intact.
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dailymed-instance:genericMe... |
Sodium Lactate
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dailymed-instance:fullName |
Sodium Lactate (Injection, Solution)
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dailymed-instance:adverseRe... |
Reactions which may
occur because of the solution or the technique of administration include
febrile response, infection at the site of injection, venous thrombosis
or phlebitis extending from the site of injection, extravasation and
hypervolemia. If an adverse
reaction does occur, discontinue the infusion, evaluate the patient,
institute appropriate therapeutic countermeasures, and save the
remainder of the fluid for examination if deemed necessary.
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dailymed-instance:warning |
Sodium Lactate
Injection, USP should be used with great care, if at all, in patients
with congestive heart failure, severe renal insufficiency, and in
clinical states in which there exists edema with sodium retention. Sodium Lactate
Injection, USP should be used with great care in patients with metabolic
or respiratory alkalosis. The administration of lactate ions should be
done with great care in those conditions in which there is an increased
level or an impaired utilization of these ions, such as severe hepatic
insufficiency. The intravenous
administration of these injections can cause fluid and/or solute
overloading resulting in dilution of serum electrolyte concentrations,
overhydration, congested states, or pulmonary edema. The risk of
dilutional states is inversely proportional to the electrolyte concentrations of the injection. The risk of solute overload causing
congested states with peripheral and pulmonary edema is directly
proportional to the electrolyte concentrations of the injection. Excessive
administration of Sodium Lactate Injection, USP may result in
significant hypokalemia. In patients with
diminished renal function, administration of Sodium Lactate Injection,
USP may result in sodium retention. Sodium Lactate
Injection, USP is not for use in the treatment of lactic
acidosis.
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dailymed-instance:indicatio... |
Sodium Lactate
Injection, USP is indicated as a source of water, electrolytes, and
calories or as an alkalinizing agent.
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dailymed-instance:represent... | |
dailymed-instance:routeOfAd... | |
dailymed-instance:name |
Sodium Lactate
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