Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/543
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Ethiodol (Injection)
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The hysterosalpingogram is preferably taken during the patient's preovulatory phase (as determined from her basal body temperature record) and not less than two days after cessation of her menstrual flow. It has been frequently observed that some bleeding will occur during or after the onset of pregnancy which cannot be distinguished by the patient from a normal menstrual period. In such cases a basal body temperature record will reveal a sustained high temperature phase, and thus enable an operator to avoid hysterosalpingography when a pregnancy may exist. Salpingography should not be performed if the blood is exuding from the cervical os (which occasionally occurs without the patient being aware of it) or if any gross evidence of endocervicitis exists. Careful aseptic technique should be employed as for any operative procedure in which the uterus is entered. A self-retaining cannula should be used thereby permitting removal of the vaginal speculum so that the outline of the cervical canal may be seen in the film. The use of a radio-opaque aluminum speculum may be employed in patients where a lacerated or patulous cervix does not permit the use of a retaining cannula. The radio-opaque agent is introduced under pressure and preferably with fluoroscopic control. A preliminary film is exposed and a skiagram is made after the injection of 5 mL of the agent. The pressure is raised to 80-90 mm Hg. In cases of normal bilateral tubal patency, the pressure falls immediately to below 60 mm Hg. The wet film may be viewed immediately and if both tubes are seen to "fill", the apparatus is removed and the procedure is finished, except for the 24 hour follow-up to establish whether or not "spill" into the peritoneal cavity has occurred. Increments of 2 mL of the agent are injected and successive films exposed until tubal patency is established or until the patient's limit of tolerance to discomfort is reached. Few patients will complain of discomfort at pressures under 200 mm Hg.
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| dailymed-instance:descripti... |
Ethiodol, brand of ethiodized oil, is a sterile injectable radio-opaque diagnostic agent for use in hysterosalpingography and lymphography. It contains 37% iodine (475 mg/mL) organically combined with ethyl esters of the fatty acids (primarily as ethyl monoiodostearate and ethyl diiodostearate) of poppyseed oil. Stabilized with poppyseed oil, 1%. The precise structure of Ethiodol is unknown at this time. Ethiodol is a straw to amber colored, oily fluid, which because of simplified molecular structure, possesses a greatly reduced viscosity (1.280 specific gravity at 15��C yields viscosity of 0.5 - 1.0 poise). This high fluidity provides a new flexibility for radiographic exploration.
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| dailymed-instance:clinicalP... |
There has been little detailed investigation of the metabolic fate of Ethiodol in either man or animals. However, the fate of Ethiodol following Lymphangiography in dogs has been reported.Koehler et al. employed I���tagged Ethiodol for lymphangiography in dogs and analyses of individual organs at various time intervals were done. The investigators reported an average of only 25% of the injected medium was retained in the lymphatics at the end of three days. An average of 50% was recovered from the lungs. They found the remainder of injected activity was fairlyuniformly distributed throughout the body. Urinary excretion in the form of inorganic iodine was revealed as the chief mode of iodine loss from the system.
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Ethiodol is contraindicated in patients hypersensitive to it. Ethiodol should not be injected intrathecally or intravascularly, or used in bronchography. A history of sensitivity to iodine contraindicates the use of Ethiodol; iodine is split off from fatty compounds and becomes free iodine in the body. Hysterosalpingography is contraindicated in intrauterine pregnancy, acute pelvic inflammatory disease, marked cervical erosion, endocervicitis in the presence of intrauterine bleeding, in the immediate pre-or postmenstrual phase, or within 30 days of curettage or conization.
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Ethiodol (ethiodized oil for injection) is supplied in a box of two 10 ml ampules, NDC 0281-7062-37. Store at controlled room temperature 15��-30��C (59��-86��F). Protect from light. Remove from carton only upon use. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Ethiodol brand of ethiodized oil for injection is straw to amber color under normal conditions. . A development of Guerbet Laboratories.
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ethiodized oil
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| dailymed-instance:fullName |
Ethiodol (Injection)
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| dailymed-instance:adverseRe... |
Hypersensitivity reactions, foreign body reactions and exacerbation of pelvic inflammatory disease, although infrequent, have been reported. In an occasional patient, abdominal pains may occur. Such pains may be the result of tubal torsion, or possibly due to too rapid a rate of instillation or excessive pressure, or both. The condition is usually only transitory, lasting one or two hours at most, and may be relieved by the administration of any of the commonly used analgesics.
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| dailymed-instance:warning |
Ethiodol is not intended for use in bronchography and, therefore, is not to be introduced into the bronchial tree. A history of sensitivity to iodine or to other contrast materials is not an absolute contraindication to Ethiodol, but calls for extreme caution. All procedures utilizing contrast media carry a definite risk of adverse reactions. While most reactions are minor, life threatening and fatal reactions may occur withoutwarning. The risk/benefit factor should always be carefully evaluated. At all times a fully equipped emergency cart and resuscitation equipment should be readily available, and personnel competent in recognizing and treating reactions of all severity should be on hand.
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Ethiodol
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