. . "Diphenhydramine Hydrochloride (Injection)" . "THIS PRODUCT IS FOR\nINTRAVENOUS OR INTRAMUSCULAR ADMINISTRATION ONLY. Diphenhydramine\nHydrochloride Injection is indicated when the oral form is impractical. DOSAGE SHOULD BE\nINDIVIDUALIZED ACCORDING TO THE NEEDS AND THE RESPONSE OF THE\nPATIENT.
Pediatric Patients,\nOther Than Premature Infants and Neonates: 5 mg/kg/24\nhours or 150 mg/m/24 hours. Maximum daily dosage is\n300 mg. Divide into four doses, administered intravenously at a\nrate generally not exceeding 25 mg/min, or deep\nintramuscularly.
Adults: 10 to 50 mg intravenously at a rate generally not exceeding 25 mg/min, or\ndeep intramuscularly; 100 mg if required; maximum daily dosage\nis 400 mg. Parenteral drug products should be\ninspected visually for particulate matter and discoloration\nprior to administration, whenever solution and container\npermit." . "Diphenhydramine\nHydrochloride Injection is a sterile, nonpyrogenic solution for\nintravenous or deep intramuscular use as an antihistaminic agent. Each\nmL contains diphenhydramine hydrochloride 50 mg and benzethonium\nchloride 100 mcg in Water for Injection. pH 4.0-6.5; sodium hydroxide and/or hydrochloric acid added, if needed, for pH adjustment. The chemical name\nof diphenhydramine hydrochloride is\n2-(Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride. The structural\nformula is as follows: CHNO\uFFFD\uFFFD\uFFFDHCl MW 291.82 Diphenhydramine\nhydrochloride occurs as a white crystalline powder and is freely soluble\nin water and alcohol." . "Diphenhydramine\nhydrochloride is an antihistamine with anticholinergic (drying) and\nsedative side effects. Antihistamines appear to compete with histamine\nfor cell receptor sites on effector cells. Diphenhydramine\nhydrochloride in the injectable form has a rapid onset of action.\nDiphenhydramine is widely distributed throughout the body, including the\nCNS. A portion of the drug is excreted unchanged in the urine, while the\nrest is metabolized via the liver. Detailed information on the\npharmacokinetics of Diphenhydramine Hydrochloride Injection is not\navailable." . . "Use in Neonates or Premature Infants: This drug\nshould not be\nused in neonates or premature infants.
Use in Nursing\nMothers: Because of\nthe higher risk of antihistamines for infants generally, and for\nneonates and prematures in particular, antihistamine therapy is\ncontraindicated in nursing mothers.
Use as a Local\nAnesthetic: Because of\nthe risk of local necrosis, this drug should not be used as a\nlocal anesthetic.
Antihistamines are\nalso Contraindicated in the Following Conditions: Hypersensitivity to diphenhydramine hydrochloride and other\nantihistamines of similar chemical structure." . "Diphenhydramine\nHydrochloride Injection, USP 50 mg/mL 1 mL DOSETTE vials\npackaged in 25s (NDC 0641-0376-25)
Storage: Protect from light. Keep covered in\ncarton until time of use. Store at 20\uFFFD\uFFFD-25\uFFFD\uFFFDC (68\uFFFD\uFFFD-77\uFFFD\uFFFDF),\nexcursions permitted to 15\uFFFD\uFFFD-30\uFFFD\uFFFDC (59\uFFFD\uFFFD-86\uFFFD\uFFFDF) [see USP\nControlled Room Temperature]. Baxter and\nDosette are trademarks of Baxter International Inc., or its\nsubsidiaries. Manufactured by Baxter Healthcare\nCorporation Deerfield,\nIL 60015 USA For Product Inquiry 1 800 ANA DRUG (1-800-262-3784) MLT-43/1.0" . . . . . . "General: Diphenhydramine hydrochloride has an atropine-like action and,\ntherefore, should be used with caution in patients with a\nhistory of bronchial asthma, increased intraocular pressure,\nhyperthyroidism, cardiovascular disease or hypertension. Use\nwith caution in patients with lower respiratory disease,\nincluding asthma.
Information for\nPatients: Patients\ntaking diphenhydramine hydrochloride should be advised that this\ndrug may cause drowsiness and has an additive effect with\nalcohol. Patients\nshould be warned about engaging in activities requiring mental\nalertness, such as driving a car or operating appliances,\nmachinery, etc.
Drug Interactions: Diphenhydramine hydrochloride has additive effects with alcohol\nand other CNS depressants (hypnotics, sedatives, tranquilizers,\netc.) MAO\ninhibitors prolong and intensify the anticholinergic (drying)\neffects of antihistamines.
Carcinogenesis,\nMutagenesis, Impairment of Fertility: Long-term\nstudies in animals to determine mutagenic and carcinogenic\npotential have not been performed.
Pregnancy:
Teratogenic\nEffects\uFFFD\uFFFD\uFFFDPregnancy Category B: Reproduction studies have been performed in rats and\nrabbits at doses up to 5 times the human dose and have\nrevealed no evidence of impaired fertility or harm to\nthe fetus due to diphenhydramine hydrochloride. There\nare, however, no adequate and well-controlled studies in\npregnant women. Because animal reproduction studies are\nnot always predictive of human response, this drug\nshould be used during pregnancy only if clearly\nneeded.
Pediatric Use: Diphenhydramine should not be used in neonates and premature\ninfants . Diphenhydramine may diminish mental alertness, or in the young\npediatric patient, cause excitation. Overdosage may cause\nhallucinations, convulsions or death . See also\nDOSAGE AND ADMINISTRATION section." . "Antihistamine\noverdosage reactions may vary from central nervous system depression to\nstimulation. Stimulation is particularly likely in pediatric patients.\nAtropine-like signs and symptoms, dry mouth; fixed, dilated pupils;\nflushing, and gastrointestinal symptoms may also occur. Stimulants should not be used. Vasopressors may be\nused to treat hypotension." . "diphenhydramine hydrochloride" . "Diphenhydramine Hydrochloride (Injection)" . "The most frequent\nadverse reactions are italicized.
General: Urticaria;\ndrug rash; anaphylactic shock; photosensitivity; excessive\nperspiration; chills; dryness of mouth, nose and\nthroat.
Cardiovascular\nSystem: Hypotension, headache, palpitations, tachycardia,\nextrasystoles.
Hematologic System: Hemolytic\nanemia, thrombocytopenia, agranulocytosis.
Nervous System: Sedation, sleepiness, dizziness, disturbed coordination,\nfatigue, confusion, restlessness, excitation, nervousness,\ntremor, irritability, insomnia, euphoria, paresthesia, blurred\nvision, diplopia, vertigo, tinnitus, acute labyrinthitis,\nneuritis, convulsions.
Gastrointestinal\nSystem: Epigastric distress, anorexia,\nnausea, vomiting, diarrhea, constipation.
Genitourinary\nSystem: Urinary\nfrequency, difficult urination, urinary retention, early\nmenses.
Respiratory System: Thickening of bronchial\nsecretions, tightness of chest and wheezing, nasal\nstuffiness." . "Antihistamines\nshould be used with considerable caution in patients with narrow-angle\nglaucoma, stenosing peptic ulcer, pyloroduodenal obstruction,\nsymptomatic prostatic hypertrophy or bladder-neck obstruction. Local necrosis has\nbeen associated with the use of subcutaneous or intradermal use of\nintravenous diphenhydramine.
Use in Pediatric\nPatients: In\npediatric patients, especially, antihistamines in overdosage may cause\nhallucinations, convulsions or death. As in\nadults, antihistamines may diminish mental alertness in\npediatric patients. In the young pediatric patient,\nparticularly, they may produce excitation.
Use in the Elderly\n(approximately 60 years or older): Antihistamines are more likely to cause dizziness, sedation and\nhypotension in elderly patients." . "Diphenhydramine\nHydrochloride Injection is effective in adults and pediatric patients,\nother than premature infants and neonates, for the following conditions\nwhen the oral form is impractical:
Antihistaminic: For\namelioration of allergic reactions to blood or plasma, in\nanaphylaxis as an adjunct to epinephrine and other standardmeasures after the acute symptoms have been controlled and for\nother uncomplicated allergic conditions of the immediate type\nwhen oral therapy is impossible or contraindicated.
Motion Sickness: For active\ntreatment of motion sickness.
Antiparkinsonism: For use in\nparkinsonism, when oral therapy is impossible or\ncontraindicated, as follows: parkinsonism in the elderly who are\nunable to tolerate more potent agents, mild cases of\nparkinsonism in other age groups and in other cases of\nparkinsonism in combination with centrally acting\nanticholinergic agents." . . . "Diphenhydramine Hydrochloride" .