Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3702
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Lactated Ringer's (Solution, For Slush)
|
| dailymed-instance:dosage |
The volume of
slushed solution required will vary with patient's age, clinical
condition, cooling effect desired and duration of cooling effect
desired, according to physician's instructions.
|
| dailymed-instance:descripti... |
Lactated Ringer's
Irrigation in the Baxter Sterile Container System is a sterile,
nonpyrogenic, isotonic solution for the preparation of slushed solution.
It contains no antimicrobial agents. Composition, osmolarity, pH, ionic
concentration and caloric content are shown in Table 1. The Baxter Sterile
Container System is designed to provide a slush container with asterile exterior surface for use
within the surgical field. Within the overwrap, the unit is packaged in
a dispensing bag which maintains the sterility of this surface. The flexible
plastic slush container is fabricated from a specially formulated
polyvinyl chloride (PL 146 Plastic). The amount of water that can
permeate from inside the container into the overwrap is insufficient to
affect the solution significantly. Solutions in contact with the plastic
container can leach out certain of its chemical components in very small
amounts within the expiration period, e.g., di-2-ethylhexyl phthalate
(DEHP), up to 5 parts per million. However, the safety ofthe plastic
has been confirmed in tests in animals according to USP biological tests
for plastic containers as well as by culture toxicity
studies.
|
| dailymed-instance:clinicalP... |
Slushed solution is
used to induce regional hypothermia in conditions such as certain open
heart and kidney surgical procedures by direct application of slushed
solution. The objective of regional hypothermia is to reduce cellular
metabolic activity so that body tissues can tolerate a period of total
or relative ischemia thereby inhibiting the formation and buildup of
destructive autolytic enzymes and anaerobic by-products usually produced
and accumulated in ischemic tissues.
|
| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
None
known
|
| dailymed-instance:supply |
Lactated Ringer's
Irrigation in the Baxter Sterile Container System is supplied as
follows: Exposure of
pharmaceutical products to heat should be minimized. Avoid excessive
heat. Avoid freezing except during controlled slushing procedure. It is
recommended that this product be stored at room temperature (25��C);
brief exposure up to 40��C does not adversely affect this
product.
|
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:precautio... |
Avoid prolonged
direct contact between ice crystals and body tissues. Experience in use
of slushed solutions in pediatrics is limited.<br/>Carcinogenesis and
Mutagenesis and Impairment of Fertility: Studies
performed with slushed Lactated Ringer's Irrigation have not
been performed to evaluate carcinogenic potential, mutagenic
potential, or effects on fertility.<br/>Pregnancy:<br/>Teratogenic Effects:<br/>Nursing Mothers: It is not
known whether this drug is excreted in human milk. Because many
drugs are excreted in human milk, caution should be exercised
when slushed Lactated Ringer's irrigation is administered to a
nursing mother.<br/>Pediatric Use: Safety and
effectiveness of slushed Lactated Ringer's Irrigation in
pediatric patients have not been established by adequate and
well controlled trials; however, the use of electrolyte
solutions in the pediatric population is referenced in the
medical literature. The
warnings, precautions and adverse reactions identified in the
label copy should be observed in the pediatric population. Do not
administer unless seals of outer dispensing bag are
intact.
|
| dailymed-instance:genericMe... |
Sodium Chloride, Sodium Lactate, Potassium Chloride and Calcium Chloride
|
| dailymed-instance:fullName |
Lactated Ringer's (Solution, For Slush)
|
| dailymed-instance:adverseRe... |
No serious adverse
reactions are known.
|
| dailymed-instance:warning |
Not for injection.
For use in slush preparation for regional hypothermia.
|
| dailymed-instance:indicatio... |
Slushed solution is
used to create regional hypothermia in order to reduce and minimize
manifestations of warm-temperature ischemia. Temperature probes may be
used to determine requirements for replacement or addition of slushed
solution.
|
| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Lactated Ringer's
|