Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1946
| Subject | Predicate | Object | Context |
|---|---|---|---|
| dailymed-drugs:1946 | rdf:type | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:1946 | rdf:type | dailymed-instance:drugs | lld:dailymed |
| dailymed-drugs:1946 | rdfs:label | BETHANECHOL CHLORIDE (Tablet) | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:dosage | Dosage must be individualized, depending on type and severity of the condition to be treated. Preferably, give the drug when the stomach is empty. If taken soon after eating, nausea and vomiting may occur. The usual adult oral dose ranges from 10 to 50 mg three or four times a day. The minimum effective dose is determined by giving 5 to 10 mg initially, and repeating the same amount at hourly intervals until satisfactory response occurs, or until a maximum of 50 mg has been given. The effects of the drug sometimes appear within 30 minutes, and are usually maximal within 60 to 90 minutes. The drugs effects persist for about one hour. If necessary, the effects of the drug can be abolished promptly by atropine . | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:clinicalP... | Bethanechol chloride acts principally by producing the effects of stimulation of the parasympathetic nervous system. It increases the tone of the detrusor urinae muscle, usually producing a contraction sufficiently strong to initiate micturition and empty the bladder. It stimulates gastric motility, increases gastric tone, and often restores impaired rhythmic peristalsis. Stimulation of the parasympathetic nervous system releases acetylcholine at the nerve endings. When spontaneous stimulation is reduced and therapeutic intervention is required, acetylcholine can be given, but is rapidly hydrolyzed by cholinesterase, and its effects are transient. Bethanechol chloride is not destroyed by cholinesterase and its effects are more prolonged than those of acetylcholine. Effects on the G.I. and urinary tract sometimes appear within 30 minutes after oral administration of bethanechol chloride, but more often 60-90 minutes are required to reach maximum effectiveness. Following oral administration, the usual duration of action of bethanechol is one hour, although large doses (300-400 mg) have been reported to produce effects for up to six hours. Subcutaneous injection produces a more intense action on bladder muscle than does oral administration of the drug. Because of the selective action of bethanechol, nicotinic symptoms of cholinergic stimulation are usually absent or minimal when orally or subcutaneously administered in therapeutic doses, while muscarinic effects are prominent. Muscarinic effects usually occur within 5-15 minutes after subcutaneous injection, reach a maximum in 15-30 minutes, and disappear within two hours. Doses that stimulate micturition and defecation and increase peristalsis do not ordinarily stimulate ganglia or voluntary muscles. Therapeutic test doses in normal human subjects have little effect on heart rate, blood pressure, or peripheral circulation. Bethanechol chloride does not cross the bloodbrain barrier because of its charged quaternary amine moiety. The metabolic fate and mode of excretion of the drug have not been elucidated. A clinical studywas conducted on the relative effectiveness of oral and subcutaneous doses of bethanechol chloride on the stretch response of bladder muscle in patients with urinary retention. Results showed that 5 mg of the drug given subcutaneously stimulated a response that was more rapid in onset and of a larger magnitude than an oral dose of 50 mg, 100 mg, or 200 mg. All the oral doses, however, had a longer duration of effect than the subcutaneous dose. Although the 50 mg oral dose caused little change in intravesical pressure in this study, this dose has been found in other studies to be clinically effective in the rehabilitation of patients with decompensated bladders. | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:activeIng... | dailymed-ingredient:bethane... | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:supply | Bethanechol Chloride Tablets, USP is available as follows: 10 mg: white, scored tablet, coded���WPC 004���on scored side and���DUVOID 10���on smooth side. NDC 67767-144-01: bottle of 100 25 mg: white, scored tablet, coded���WPC 005���on scored side and���DUVOID 25���on smooth side. NDC 67767-145-01: bottle of 100 50 mg: tan, scored tablet, coded���WPC 006���on scored side and���DUVOID 50���on smooth side. NDC 67767-146-01: bottle of 100 Dispense in a tight container as defined in the USP. Store at 25��C (77��F); excursions permitted to 15��-30��C (59��-86��F) [See USP Controlled Room Temperature]. Keep this and all medication out of the reach of children. | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:activeMoi... | dailymed-ingredient:bethane... | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:inactiveI... | dailymed-ingredient:corn_st... | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:inactiveI... | dailymed-ingredient:magnesi... | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:inactiveI... | dailymed-ingredient:microcr... | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:inactiveI... | dailymed-ingredient:calcium... | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:genericMe... | bethanechol chloride | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:fullName | BETHANECHOL CHLORIDE (Tablet) | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:adverseRe... | Adverse reactions are rare following oral administration of bethanechol chloride, but are more common following subcutaneous injection. Adverse reactions are more likely to occur when dosage is increased. The following adverse reactions have been observed: Body as a Whole: Malaise. Cardiovascular: Fall in blood pressure with reflex tachycardia, vasomotor response. Digestive: Colicky pain, abdominal cramps or discomfort, diarrhea, nausea and belching, salivation, and borborygmi. Skin: Flushing, producing a feeling of warmth; sensation of heat about the face; sweating. Respiratory: Asthmatic attacks and bronchial constriction. Nervous System: Headache. Renal: Urinary urgency. Special Senses: Lacrimation, miosis. Causal Relationship Unknown: The following adverse reactions have been reported, and a causal relationship to therapy with bethanechol chloride has not been established: Body as a Whole: Malaise. Nervous System: Seizures. | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:indicatio... | Bethanechol chloride is indicated for the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention, and neurogenic atony of the urinary bladder with retention. | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:represent... | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:routeOfAd... | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:1946 | dailymed-instance:name | BETHANECHOL CHLORIDE | lld:dailymed |
| http://www4.wiwiss.fu-berli... | dailymed-instance:producesD... | dailymed-drugs:1946 | lld:dailymed |