Linked Life Data

CPATH-95317

Source:http://cbio.mskcc.org/cpath#CPATH-95317

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SubjectPredicateObjectContext
cpath:CPATH-95317rdf:typehttp://www.biopax.org/relea...lld:biogrid
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cpath:CPATH-95317http://www.biopax.org/relea...cpath:CPATH-LOCAL-402067lld:biogrid
cpath:CPATH-95317http://www.biopax.org/relea...Putative ATP-dependent Clp protease proteolytic subunit, mitochondriallld:biogrid
cpath:CPATH-95317http://www.biopax.org/relea...CLPP_HUMANlld:biogrid
cpath:CPATH-95317http://www.biopax.org/relea...cpath:CPATH-LOCAL-393574lld:biogrid
cpath:CPATH-95317http://www.biopax.org/relea...Endopeptidase Clplld:biogrid
cpath:CPATH-95317http://www.biopax.org/relea...3.4.21.92lld:biogrid
cpath:CPATH-95317http://www.biopax.org/relea...FUNCTION: Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. CATALYTIC ACTIVITY: Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). SUBUNIT: Tetradecamer that assembles into a two heptameric rings with a central cavity. SUBCELLULAR LOCATION: Mitochondrion matrix. TISSUE SPECIFICITY: Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney. SIMILARITY: Belongs to the peptidase S14 family. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-95317skos:exactMatchuniprot-protein:Q16740lld:mappings
cpath:CPATH-95317skos:closeMatchentrez-gene:8192lld:mappings
cpath:CPATH-LOCAL-11541039http://www.biopax.org/relea...cpath:CPATH-95317lld:biogrid