| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Scavenger receptor class B member 1
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| http://www.biopax.org/relea... |
SCRB1_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CD36,
CD36 and LIMPII analogous 1,
CD36 antigen-like 1,
CLA-1,
Collagen type I receptor, thrombospondin receptor-like 1,
SR-BI,
SRB1
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| http://www.biopax.org/relea... |
FUNCTION: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity). SUBUNIT: Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. The C- terminal region binds to PDZK1 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=3; IsoId=Q8WTV0-1; Sequence=Displayed; Note=May be due to a competing donor splice site. No experimental confirmation available; Name=1; Synonyms=SR-BI; IsoId=Q8WTV0-2; Sequence=VSP_008554; Name=2; Synonyms=SR-BII; IsoId=Q8WTV0-3; Sequence=VSP_008553, VSP_008554; Name=4; Synonyms=SR-BIII; IsoId=Q8WTV0-4; Sequence=VSP_011037, VSP_008554; TISSUE SPECIFICITY: Widely expressed. PTM: N-glycosylated. POLYMORPHISM: Genetic variations in SCARB1 define the high density lipoprotein cholesterol level quantitative trait locus 6 (HDLCQ16) [MIM:610762]. SIMILARITY: Belongs to the CD36 family. GENE SYNONYMS: CD36L1 CLA1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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