| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-262689,
cpath:CPATH-LOCAL-262689,
cpath:CPATH-LOCAL-262690,
cpath:CPATH-LOCAL-262690,
cpath:CPATH-LOCAL-262691,
cpath:CPATH-LOCAL-262691,
cpath:CPATH-LOCAL-262692,
cpath:CPATH-LOCAL-262692,
cpath:CPATH-LOCAL-262693,
cpath:CPATH-LOCAL-262693,
cpath:CPATH-LOCAL-270235,
cpath:CPATH-LOCAL-270235
|
| http://www.biopax.org/relea... |
Suppressor of cytokine signaling 6,
Suppressor of cytokine signaling 6
|
| http://www.biopax.org/relea... |
SOCS6_HUMAN,
SOCS6_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CIS-4,
CIS-4,
Cytokine-inducible SH2 protein 4,
Cytokine-inducible SH2 protein 4,
SOCS-4,
SOCS-4,
SOCS-6,
SOCS-6,
Suppressor of cytokine signaling 4,
Suppressor of cytokine signaling 4
|
| http://www.biopax.org/relea... |
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with RBCK1. Interacts with phosphorylated IRS4 (By similarity). Interacts with PIM3 (By similarity). DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). SIMILARITY: Contains 1 SH2 domain. SIMILARITY: Contains 1 SOCS box domain. GENE SYNONYMS: CIS4 SOCS4. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with RBCK1. Interacts with phosphorylated IRS4 (By similarity). Interacts with PIM3 (By similarity). DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). SIMILARITY: Contains 1 SH2 domain. SIMILARITY: Contains 1 SOCS box domain. GENE SYNONYMS: CIS4 SOCS4. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |